Formulation and Evaluation of Taste Masking Metoclopramide Hydrochloride Rapid-Disintegrating Tablets
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2014, Vol 2, Issue 4
Abstract
In the present work, rapid disintegrating tablets of Metoclopramide hydrochloride were prepared by direct compression method with a view to enhance patient compliance. The bitter taste of Metoclopramide hydrochloride was masked using Eudragit E 100 by mass extrusion method. Two superdisintegrant, viz., crospovidone and sodium starch glycolate were used in different ratio (3-7% w/w) separately and in combination. The taste-masked powder was analyzed for percentage drug content percentage yield. Taste masking was confirmed by dissolving the mass extruded power in acidic buffer pH 6.8. The prepared batches of tablets were evaluated for thickness, weight variation, hardness, friability, drug content uniformity, wetting time, water absorption ratio, In-vitro disintegration time and In-vitro drug release. The results of pre and post compression studies of all the formulations were well within the compendia limits. Based on disintegration time (approximately 11 seconds) and percentage drug release is 50.90 after 2 min and 102.06 after 10 min. formulation F3 containing 7% crospovidone was considered to be the best formulation.
Authors and Affiliations
B. Udhyakumar, V. Kamalakkannan, R. Sambathkumar
Keywords
Related Articles
- EP ID EP33236
- DOI -
- Views 322
- Downloads 0
Anti-osteoporotic effect of Urtica dioica on ovariectomised rat
This study was undertaken to check the anti-osteoporotic activity of Urtica dioica on ovariectomised (OVX) rats. Bilateral ovariectomy was performed in rats under aseptic condition and ether anaesthesia. Healthy albino...
REVIEW ARTICLE ON ANTIMICROBIAL RESISTANCE
Antimicrobial resistance (AMR) is not a recent phenomenon, but it is a critical health issue today. Over several decades, to varying degrees, bacteria causing common infections have developed resistance to each new ant...
Formulation and evaluation of floating bilayer tablets of propranolol hydrochloride
Propranolol hydrochloride bi-layered, gastro-retentive floating tablets were formulated to increase the residence time of the drug by direct compression technique. The first layer of sustained layer was punched and sec...
PREPARATION, CHARACTERIZATION AND EVALUATION OF OLMESARTAN MEDOXOMIL-Β CYCLODEXTRIN COMPLEXES
Olmesartan medoxomil is a poor water soluble drug. There are numerous approaches available and reported in literature to enhance the solubility of poor water soluble drugs among which cyclodextrin complexation is predo...
Marketing Authorization Application (MAA) representation for preparation of DMF’s in European for active pharmaceutical ingredient
In this type of work a comparative study on marketing authorization application (MAA) representation for Preparation of Drug master files (DMF) in Europe for Active pharmaceutical ingredient (API) was reviewed thorough...