FORMULATION AND EVALUATION OF THEOPHYLLINE CONTROLLED RELEASE MATRIX TABLETS USING HPMC AS POLYMER
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2012, Vol 3, Issue 7
Abstract
Theophylline controlled release matrix tablets were prepared with HPMC K100M in two ratios and with three different hardness of 5, 6 and 7kg/cm2. Theophylline controlled release granules were prepared and evaluated for the angle of repose, bulk density, tapped density, compressibility index and hausners ratio. All the formulation showed good flow properties. The compressed tablets were evaluated for the hardness, uniformity of weight, friability, drug content and invitro dissolution studies. All the formulations showed compliance with pharmacopoeial standards. There was no interaction between drug, polymer and other excipients. It was confirmed by FTIR studies. Among all the formulations F6 (i.e. polymer ratio1:2 and hardness 7kg/cm2) showed prolong release when compare to other formulations. The drug release kinetics showed zero order. The optimum formulation (F6) was stable when it was stored at 40 + 20 C, 270 + 20 C and at 450 + 20 C for 6 months.
Authors and Affiliations
N. R Sivakumar, S Chandra, T Kumar, S. K Kanthlal, R. S Jayaseelan
Keywords
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