Formulation and evaluation of transdermal patch containing amphotericin B
Journal Title: International Journal of Novel Trends in Pharmaceutical Sciences - Year 2015, Vol 5, Issue 4
Abstract
Transdermal drug delivery system are topically administered medicaments in the form of patches that deliver drugs for systemic effects at a predetermined and controlled rate. These devices allow for pharmaceuticals to be delivered accross the skin barrier. The human skin is a readily accessible surface for drug delivery. It is an alternative to oral delivery and hypodermic injection. In addition, transdermal system are non-invasive and can be self administered. Amphotericin B is effective against serious or life-threatening systemic fungal infection but not to treat less serious fungal infection of mouth,throat or vagina. It is insoluble in water and having high permeability through stomach. This results in poor bioavailability after oral administration. Therefore transdermal patch containing Amphotericin B was formulated to increase its solubility, bioavailability and patient compliance. solvent casting method was used to formulate transdermal patch. PEG was selected as the permeation enhancer and Glycerin was selected as plasticizer for the formulation and mixed with different concentration of polymeric casting solution which contains HPMC (polymer at different ratios) and Chloroform:Methanol at 1:1 ratio used as solvent. Formulated transdermal patch were then evaluated for drug content, weight variation, flatness, folding endurance, % moisture content, tensile strength, and physical appearance. The in vitro drug diffusion studies revealed that transdermal patch formulation that is F1 shows better drug release profile (97.87%) when compared with other formulations.
Authors and Affiliations
B. Thejeswi , Subhashis Debnath , M Niranjan Babu
Formulation and evaluation of transdermal patch containing amphotericin B
Transdermal drug delivery system are topically administered medicaments in the form of patches that deliver drugs for systemic effects at a predetermined and controlled rate. These devices allow for pharmaceuticals to be...
Formulation and evaluation of nanoemulsion of amphotericin B
Amphotericin B is a synthetic antifungal drug. It is insoluble in water and having high permeability through stomach. This results in poor bioavailability after oral administration. Therefore nanoemulsion containing Amph...
Homology modeling and domain analysis studies on (CHRNA5) lung cancer protein using bioinformatics methods
Globally, lung cancer is the most common cancer among men in terms of both incidence and mortality and among women has the third highest incidence, and is second after breast cancer in mortality. The aim of the research...
Synthesis, characterisation and anthelminthic activity of some novel 1, 4 Disubstituted azetidinones
Heterocyclic synthesis has emerged as a powerful technique for generating new chemical entities useful for drug discovery. Heterocyclic compounds provide scaffolds on which pharmacophores can be arranged to obtain potent...
Preparation and standardization of biocompost with sugar and distillery industry wastes using selected microbial species
For the present study, the presmud and distillery industry wastes were collected at M/S Rajshree Sugars and Chemicals Limited, Varadaraj Nagar, Theni district, Tamilnadu, India, used sterile polythene container and broug...