Formulation and in-vitro evaluation of Aceclofenac loaded topical Emulgel
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2014, Vol 2, Issue 6
Abstract
Gels are a relatively newer class of dosage form created by entrapment of large amounts of aqueous or hydro alcoholic liquid in a network of colloidal solid particles. Gel formulations generally provide faster drug release compared with conventional ointments and creams. In spite of many advantages of gels, a major limitation is in the difficulty in delivery of hydrophobic drugs. So to overcome these limitations, emulgels are prepared. When gels and emulsions are used in combined form, the dosage forms are referred as Emulgels. Emulsions possess a certain degree of elegance and are easily washed off whenever desired. They also have a high ability to penetrate the skin. Emulgels for dermatological use have several favourable properties such as being thixotropic, greaseless, easily spreadable, easily removable, emollient, non-staining, water-soluble, longer shelf life, bio-friendly, transparent & pleasing appearance. Other important factor is to extend the drug release of even hydrophilic drugs by making w/o emulgel, Aceclofenac is an anti-inflammatory drug and is successfully used in the treatment for the relief of pain and inflammation in rheumatoid arthritis, osteoarthritis and ankylosing spondylitis lipophilic drug with biological halflife 4 hrs. On this contest, emulgel was formulated using carbopol 934 and CMC, liquid paraffin as oil phase, emulsifying agents like tween 20 and span 20 and propylene glycol as permeation enhancers.
Authors and Affiliations
Syed Abdul Khalid, B. Pragati Kumar, T. Abhinov
Keywords
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