FORMULATION AND INVITRO/ INVIVO EVALUATION OF DRIED NANOSUSPENSIONS OF NEBIVOLOL
Journal Title: Indo American Journal of Pharmaceutical Research - Year 2017, Vol 7, Issue
Abstract
Abstract In the present study, an attempt was made to prepare oral Nanosuspension of Nebivolol (a beta1 blocker), in order increase drug solubility and to overcome bioavailability problems, to reduce dose dependent side effects and frequency of administration. Nanosuspension containing the drug was prepared by precipitation method using combinations of polymers (such as tween 80, tween 20, soluplus, PEG 200, PEG 400 and methanol) in to 12 formulations F1to F12. Subsequent drying was done by spray drying method to form dried nanosuspensions. The Nanosuspensions were evaluated for particle size, zeta potential, drug content uniformity, in-vitro drug release, short-term stability, and drug- excipient interactions (FTIR). IR spectroscopic studies indicated that there are no drug-excipient interactions. The formulation F10 containing Tween 80, Tween 20, Soluplus, PEG 200, PG, Methanol and water were found to be promising, which showed 100% drug release within 15 min when compared to the optimised formulation (Bystolic) which showed only 91.95% drug release for 20mins. SEM (scanning Electron Microscopy) analysis showed average particle size to be at 300.3nm and it also shown desired zetapotential value. Short-term stability studies indicated stability with respect to drug content and dissolution. Dried Nanosuspension of nebivolol can be prepared by precipitation method and spray drying was done. Among all the formulations, F10 was found to be promising with 100% drug release in 15mins. Short-term stability studies of the promising formulation indicated that there are no significant changes in dissolution parameter values after 3 months.
Authors and Affiliations
S. Raja shekhar*1, P. Vijaya lakshmi2
Keywords
Related Articles
- EP ID EP330673
- DOI -
- Views 103
- Downloads 0
HYPROMELLOSE AND CARBOMER INDUCE BIOADHESION OF ACYCLOVIR TABLET TO VAGINAL MUCOSA
The present research indicates fabrication of an “economic” controlled release bioadhesive vaginal tablets containing acyclovir using only two polymers; Carbopol 934P (as bioadhesive agent) and HPMC K15 (as rate retardan...
PREPARATION AND EVALUATION OF ANTI HYPERTENSIVE IR GRANULES AND ANTI DIABETIC SR MINI TABLETS FILLED CAPSULE SYSTEMS
The objective of the present study is to formulate and evaluate the Capsule system with the anti diabetic mini tablets of Glipizide and antihypertensive granules of Losartan potassium with different release patterns by u...
VOLATILE CONSTITUENTS AND BIOLOGICAL ACTIVITIES OF FRESH RHIZOME OF CURCUMA LONGA LINN.
Abstract Curcuma longa Linn. syn. Indian saffron, curcuma in hindi known as haldi (f Zingiberaceae.) is a tall herb. It is a native of South Asia & is cultivated extensively throughout warmer parts of the world, includin...
A STUDY TO ASSESS AND EVALUATE THE PRESCRIBING PATTERN OF ANTI- HYPERTENSIVE DRUGS IN A TERITARY CARE TEACHING HOSPITAL
Abstract Objective: The objectives of the study are to assess and evaluate the prescribing patterns of antihypertensive drugs in patients of a tertiary care teaching hospital,to compare the prescribing patterns of antihy...
VALIDATION OF A FORCED DEGRADATION UPLC METHOD FOR ESTIMATION OF BECLOMETHASONE DIPROPIONATE IN RESPULES DOSAGE FORM
Abstract Respules are the drugs in aqueous suspension form contained and packed in respiratory ampules, they are administered through inhalation by a device called nebulizer. The purpose of the study is to validate an UP...