Formulation, Development and Evaluation of Mouth Dissolving Tablet Containing Cyclodextrin as Taste Masker
Journal Title: IOSR Journal of Pharmacy (IOSRPHR) - Year 2019, Vol 9, Issue 1
Abstract
Mouth dissolving dosage form is very important for geriatric patients who have difficulty in swallowing tablets or in situation where access of water is not possible. The present study was carried out to prepare Telmisartan mouth dissolving tablet that can used as an antihypertensive drug. To mask the bitter taste of the drug, the drug-polymer complex (DPC) were prepared in various ratio(1:1, 1:2, 1:3, 1:4, 1:5 & 1:6) by solvent evaporation method and the characterization of DPCs were carried out by determining Drug content , invitro evaluation of drug complex & Threshold value determination. The threshold value was determined at 200µg/ml and the DPC was selected which masked the taste of drug was 1:3 ratio. Selection of superdisintegrants like crosspovidone, sodium starch glycolate, crosscarmellose sodium was carried out. Tablets were prepared along with other additives by direct compression method was used for preparation of mouth dissolving tablets. Tablets were evaluated for various tests like weight variation, hardness, friability, content uniformity, wetting time, water absorption ratio, in-vitro disintegration time, in-vitro dispersion time & dissolution.
Authors and Affiliations
Swati L. Khedekar, Subhash V. Deshmane
Keywords
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