FORMULATION DEVELOPMENT AND IN-VITRO EVALUATION OF CHRONOTHERAPEUTIC DRUG DELIVERY OF ROSUVASTATIN BY COMPRESSED COATED TECHNIQUE
Journal Title: Int J of Pharm Rev& Res - Year 2015, Vol 5, Issue 3
Abstract
Rosuvastatin is an HMG –COA reductase inhibitor, primarily used for the treatment of hyper cholestremia associated with cardiovascular diseases. It belongs to BCS class II having a half-life of 19 hrs and 20% bioavailability. The purpose of the present work was to develop a press-coated, chronotherapeutic drug delivery system. The core tablet was formulated using the super-disintegrants and croscarmellose sodium. A press-coated tablet contained the polymers ethyl cellulose, eudragit L 100 &S 100. The tablets were evaluated for physical characteristics are pre and post compression parameters, lag time, FTIR, DSC, and in vitro the 10% superdisintgrant showed good results. The FTIR and DSC study predicted no chemical interactions between the drug and excipients. The lag time for the tablet coated with 100 mg ethyl cellulose was 9±0.1 hrs with90±1.5% drug release; with 100 mg eudragit L100, the lag time was 6±0.1 hrs with 89.71±1.2% drug release; and with 100 mg eudragit S100, the lag time was6±0.2 hrs with 88±1.7% drug release. The release mechanism of the tablet followed the Korsmeyer-Peppas equation and a first-order release pattern& lag time behavior have shown good in vitro release
Authors and Affiliations
Gatla Narasimha Reddy1 , B. Arunkumar2 , Ramavath Naresh Naik2
Keywords
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