FORMULATION DEVELOPMENT OF OXYCODONE HCL SOFT GELATIN CAPSULES
Journal Title: European Journal of Biomedical and Pharmaceutical Sciences - Year 2019, Vol 6, Issue 6
Abstract
The objective of this work is to develop simple, elegant, liquid-filled immediate release soft gelatin capsules containing Oxycodone HCl intended for the management of moderate to severe pain in patients who require treatment with an oral opioid analgesic. The present work describes the design of formulation and manufacturing process of Oxycodone HCl 30 mg capsules. Manufacturing of oxycodone HCl Capsules, 30 mg, consists of two concurrent manufacturing processes: gel mass and fill material, which converge during the encapsulation process. Capsule fill material was formulated using citric acid and high molecular polyethylene glycol matrix system. The gel mass was prepared in gelatin as shell forming material, and glycerin was used as plasticizer at a 1: 0.5 ratio. The prepared soft gelatin capsules were evaluated for water content in fill material, loss on drying of shell, weight variation, burst strength, assay, and dissolution. The capsules had a fill weight of 300 mg, disintegration time less than 5 minutes, and drug release rate >85% in 15 minutes. Furthermore, Texture analysis showed the capsules had burst strength of 125.0 N with an elasticity value of 2.23 mm. With this we, conclude that oxycodone HCl immediate release soft gelatin capsules can be manufactured at commercial scale with similar composition and improved quality attributes of other existing solid dosage forms such as tablets.
Authors and Affiliations
Dr. S. Gumudavelli
Keywords
Related Articles
- EP ID EP670897
- DOI -
- Views 156
- Downloads 0
OVERVIEW OF HEPATITIS B SURFACE ANTIGEN INCIDENCE AMONG PREGNANT WOMEN IN KING HUSSEIN MEDICAL CENTRE AND PRINCE HASHEM HOSPITAL
Objective: To determine the prevalence of hepatitis B surface antigen among pregnant women presenting to antenatal care clinic in Prince Hashem Hospital in Zarqa city and King Hussein Medical Centre (KHMC) in Amman, Jord...
ANTIBODY RESPONSE OF BROILER CHICKENS FED DIETS CONTAINING YEAST SINGLE CELL AS REPLACEMENT OF SOYBEAN MEAL AGAINST NEWCASTLE DISEASE
A study was conducted to evaluate the effect of replacement of soya bean meal with yeast single cell protein on broiler antibody titer against Newcastle disease virus (NDV). A total of 120 chicks out of 150 chicks were s...
NANOSTRUCTURED LIPID CARRIER: A NOVEL APPROACH
The primary and foremost aim of writing this article is to focus on the importance and benefits of Nanostructured Lipid Carrier loaded drug delivery systems. The drug can be effectively distributed in the body by followi...
"THE POSSIBLE PROTECTIVE EFFECT OF OMEGA-3 AGAINST METOCLOPRAMIDE INDUCED HYPERLIPIDEMIA IN RATS"
Metoclopramide (MCA) is one of prokinetic drugs. It is used for the treatment upper gastrointestinal motility disorders such as diabetic gastroparesis, nausea, vomiting and gastroesophageal reflux. It increases serum pro...
ASSESSEMENT OF SOME CYTOKINES IN PREGNANCY LOSS
Background: Human pregnancy is mediated by complex immunological alterations. Objective: Assessment of some cytokines in pregnancy loss in Abia State, South East, Nigeria. Materials and Methods: This was a cross-sectiona...