FORMULATION, EVALUATION, AND OPTIMIZATION OF NOVEL SILVER SULFADIAZINE LOADED FILM FORMING HYDROGEL FOR BURNS
Journal Title: Hygeia:journal for drugs and medicines - Year 2016, Vol 8, Issue 2
Abstract
Plan:Formulation, evaluation and optimization of Silver sulfadiazine loaded film forming hydrogel using different hydrophilic polymers for the treatment of burns. Preface: Burn injuries are very complex. One of the golden treatments in topical burn is silver sulfadiazine (SSD).The film forming hydrogels (FFHs) are non- solid dosage forms that produce a flexible, occlusive film in-situ after application on the skin or any other body surface. Methodology: The hydrogel matrix was prepared with combinations of PVA & PVP, HPMC E5LV, and HPMC E15LV. The prepared FFHs were evaluated for their various physicochemical properties. The optimized formulation was selected by antimicrobial activity by agar diffusion technique. The in-vitro drug release study of optimized formulation was carried out and analyzed by potentiometric titrations. Outcome: All the formulations showed better antimicrobial activity when compared with marketed SSD cream. The formulation F3 was found to be the optimized formulation.
Authors and Affiliations
SARANYA TV, Manoj K
Keywords
Related Articles
- EP ID EP333755
- DOI 10.15254/H.J.D.Med.8.2016.156
- Views 89
- Downloads 0
DEVELOPMENT AND VALIDATION OF A RP- UFLC METHOD FOR ESTIMATION OF SYNTHETIC STEROID HORMONE DANAZOL
Plan: Danazol is a synthetic steroid hormone with anti-estrogenic and anti-gonadotropic activities drug which acts on anterior pituitary suppressant by inhibiting the pituitary output of gonadotropins indicated for the t...
NEW SPECTROPHOTOMETRIC METHOD FOR THE ESTIMATION OF ATORVASTATIN CALCIUM AND ASPIRIN USING UREA AS HYDROTROPIC SOLUBILIZING AGENT
Plan: An analytical method for the simultaneous determination of Atorvastatin and Aspirin in capsule dosage form using 1.5M urea as hydrotropic solubilizing agent is described. Prologue: The method is simple, fast, &...
UV SPECTROPHOTOMETRIC METHOD DEVELOPMENT AND VALIDATION FOR QUANTITATIVE ESTIMATION OF RUTIN
Plan: we have developed new a method for quantitative estimation of Rutin hence no UV spectroscopic method is available for the quantitative analysis of rutin for bulk analysis. Preface: U.V Spectrophotometric method ha...
HEAVY METALS IN AYURVEDIC MEDICINES
Ayurveda is the traditional medicine of India that has been practiced since ancient times. According to the modest estimates made by European scholars, it has a track record of 20 centuries. However, protagonists of the...
Synthesis and Antioxidant activity of novel Pyrazoline derivatives
Plan: A novel series of pyrazolines were synthesized through chalcones. The synthesized compounds were evaluated for various antioxidant activities. Preface: Pyrazolines belongs to five-membered nitrogen classes of co...