Formulation & Evaluation of Ciprofloxacin Solid Dispersion Controlled Release Floating Capsules for Solubility Improvement
Journal Title: Indian Journal of Pharmaceutical and Biological Research - Year 2017, Vol 5, Issue 3
Abstract
Solid dispersions in water soluble carriers have attracted considerable interests as a mean of improving the dissolution rate & hence possibly bioavailability range of hydrophobic drugs. The poor solubility of ciprofloxacin leads to poor dissolution & hence variation in bioavailability. The purpose of present investigation was formulation & evaluation of controlled release floating capsule of ciprofloxacin with improved solubility & dissolution rate. In present study solid dispersion using various carriers like mannitol & lactose in different ratios were prepared by solvent evaporation method. The prepared solid dispersions were characterized for drug content, solubility & dissolution rate. The dissolution rate substantially improved for ciprofloxacin from its solid dispersions compared with pure drug. Dissolution rate increased with increase in carrier content. The dissolution rate was increased 3 folds with solid dispersions containing 1:4 of drug: lactose. The granules of ciprofloxacin solid dispersion containing 1:4 of drug: lactose ratio was prepared by wet granulation method using polymer such as ethyl cellulose & HPMC. The prepared granules were evaluated to preformulation studies such as angle of repose (18.41-24.22), bulk density, tapped density, compressibility index (11.31-12.75) & hausner’s ratio. All the parameters shows that the granules having good flow properties. These granules had converted into the capsule forms. Then the formulated capsules were taken to the evaluation studies such as weight variation, release study, buoyancy & floating duration (more than 6 hrs.). We can conclude that all the parameters were within the acceptable limits.
Authors and Affiliations
Gaurav Subhash Katore| Sharadchandra Pawar College of Pharmacy, Dumberwadi, Pune, India, S. J. Bidkar| Assistant Professor, Department of Pharmaceutics, Sharadchandra Pawar College of Pharmacy, Dumberwadi, Pune, India, G. Y. Dama| Principal, Department of Pharmacognosy, Sharadchandra Pawar College of Pharmacy, Dumberwadi, Pune, India
Keywords
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