FORMULATION, IN-VITRO&IN-VIVO EVALUATION OF NANOEMULSION GEL FOR TRANSDERMAL DRUG DELIVERY OF NIMODIPINE
Journal Title: Asian Journal of Pharamceutical and Clinical Research - Year 2015, Vol 8, Issue 2
Abstract
 Objective: The objective of this study was to develop and evaluate the potential of nanoemulsion (NE) as drug carrier system for transdermal deliveryof nimodipine.Methods: Nimodipine NE was developed through titration method. This was then formulated in to gel. Transdermal in-vitro permeation of nimodipinethrough wistar rat abdominal skin was determined with Franz diffusion cell. The in-vitro skin permeation profile of optimized formulation wascompared with NE gel (NEG), control or drug loaded neat components.Result: Significant increase in the steady state flux (Jss), permeability coefficient (kp) and enhancement ratio was observed in the NE formulation andwere compared with other formulations. The highest value of the permeability coefficient was obtained in the optimized NE formulation consistingof 0.008% w/w of nimodipine, 8.00% w/w of triacetin:isopropyl myristate (1:1), 32.00% w/w of Smix (2:1 Tween 80 and PEG-400) and 60.00% w/wof distilled water. The bioavailability studies in wistar rat showed about 3 times improvement for transdermal administration of NEG compared withan oral suspension. The present work also evaluated the transdermal product on blood pressure of methyl prednisolone acetate induced hypertensiverats.Conclusion: The results of the present investigation suggested that NE could be a potential vehicle for improved transdermal delivery of nimodipine.Keywords: Nimodipine, Nanoemulsion, Gel, Transdermal delivery, Anti-hypertensive.
Authors and Affiliations
Sheela Akhilesh Yadav, Dinesh Kumar Singh, Sushilkumar S Poddar
Keywords
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