FORMULATION OPTIMIZATION AND EVALUATION OF LIPOSOMAL GEL OF PREDNISOLONE BY APPLYING STATISTICAL DESIGN
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2013, Vol 1, Issue 2
Abstract
Liposomal carriers, well known for their potential in topical drug delivery have been chosen to help Prednisolone molecules in the skin layers. In the present work statistical study for the formulation of liposomes for topical delivery of Prednisolone using the factorial design approach was undertaken. Amount of Soya Lecithin, DPPS and cholesterol (CH) were taken at three different levels and liposomes were prepared using film hydration technique. Gels containing liposomes (optimized batch) were prepared in Carbopol® 940P and were characterized for rheology, spreadability and permeation through the rat skin. Results of regression analysis revealed that vesicle size and entrapment efficiency were dependant on the cholesterol and lipid concentration. Rheological studies of all liposomal gels prepared with 1%, 1.5%, and 2% w/w carbopol gave a clear idea of concentration of carbopol required. Liposomal dispersion and gels were found to increase the skin permeation and deposition compared to control and marketed gel. Liposome dispersion and gel formulation were found to be stable for 60 days.
Authors and Affiliations
Varde Neha M, Thakor Namita M, C. Sini Srendran, Shah Viral H
Keywords
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