Frequency of HBV, HCV and HIV Infections and Determination of HCV Genotype Distribution in People who Inject Drugs
Journal Title: Viral Hepatitis Journal - Year 2021, Vol 27, Issue 1
Abstract
Objectives: The aim of this study was to determine the frequency of blood-borne infections [hepatitis B virus (HBV), HCV, and human immunodeficiency virus (HIV)] and the genotype distribution retrospectively in people who inject drugs (PWID). Materials and Methods: A total of 150 PWID were investigated retrospectively. HBV, HCV, HIV serologies and viral load information were recorded. Results: The mean age was 27.0±4.89 and 13 (8.7%) patients were female. One hundred and twenty six (84.0%) patients had shared injectors at least once in their lives. Anti-HCV positivity was detected in 91 (60.6%) of 150 patients, hepatitis B surface antigen positivity in 3 (2.0%) and anti-HIV positivity in 1 patient. HCV-RNA was detected in 61 of the patients with anti-HCV positivity and 48 (67.6%) of them were positive for HCV-RNA. Genotype was studied in 38 patients with HCV-RNA positivity. Genotype 1a was detected in 20 patients, genotype 3a in 12 patients, genotype 4c/d in 5 patients and 2b in 1 patient. Conclusion: In PWID, HCV infection was found to be in high ratio in PWIDs and the most common HCV genotype was 1a. It was concluded that injector sharing caused infectious diseases in PWID and that some HCV genotypes were dominant in these patients. Genotype determination will be a guide for individualized treatments in these patients.
Authors and Affiliations
Hüseyin Kara, Dilara İnan, Özgen Özçelik, Ali Erdoğan, Dilek Çolak, Gözde Öngüt
Keywords
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- EP ID EP694435
- DOI 10.4274/vhd.galenos.2021.2020-12-6
- Views 74
- Downloads 0
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