Frequency of HLA-DRB1 in Iraqi Patients with Guillain-Barre Syndrome
Journal Title: Journal of Advances in Medicine and Medical Research - Year 2014, Vol 4, Issue 34
Abstract
Background: Genetic backgrounds play an important role in susceptibility to and protection against Guillain Barré Syndrome. Certain human leukocyte antigens have been found to be associated with Guillain Barré Syndrome. Aim of Study: This study aimed to study the relationship between the susceptibility of HLA Class II "DRBI" allele's frequencies in a sample of Iraqi's patients with Guillain Barré Syndrome compared with a healthy control group using PCR-SSOP method. Patients and Methods: Thirty consecutive Iraqi Arab Muslim patients with Guillain-Barre syndrome admitted in the Neurological Department in neurosciences Hospital between September-2012 to June-2013 were assessed for HLA genotyping for HLADRB1. A control group consisted from thirty healthy volunteers among the staff of Al-Kindy College of Medicine that did not have any neurological disorders whether recent or previously and had negative family history for this diseases or other neurological disorders. HLA genotyping for HLADRB1 was performed for each patient and for the control persons using the PCR with sequence-specific oligoneucleotide primers. Allele frequencies were compared across groups. Results: There was a significant higher rate of DRB1*03:01 frequencies in patients with GBS compared with healthy controls (p=0.007, Odds ratio=5.687, 95% CI: 1.59-20.33) Conclusions: HLA-DRB1*03:01 may have association with susceptibility to Guillain-Barre syndrome.
Authors and Affiliations
Batool Mutar Mahdi, Zaki Noah Hasan
Keywords
Related Articles
- EP ID EP348887
- DOI 10.9734/BJMMR/2014/10283
- Views 74
- Downloads 0
Assessment of the Deleterious Effects of Therapeutic Antitussives on Enamel. Mapping the Chemical Profile of Over the Counter Cough Lozenges Using Analytical HPLC
Aim: 1) To evaluate and compare changes in the micro hardness of enamel after exposure to different cough lozenges. 2) To assess the pH of dissolved lozenge solutions, and 3) To analyze the number of components in cough...
Association between Major Non-communicable Diseases Risk Factors and Fasting Blood Glucose in Iran: Comparison of Two Techniques, with and Without Dichotomizing the Response
Background: Dichotomizing a continuous outcome variable is a common approach to estimate the odds ratio (OR) as a measure of association. In the present study we aimed to compare a non-dichotomizing technique with logist...
Pilot Study of Ambulatory Inguinal Hernia Repair under Ultrasound-guided Transversus Abdominis Plane Block Anesthesia Plus Conscious Sedation
Aim: Transversus abdominis plane (TAP) block is mainly used as part of multimodal postoperative analgesia regimens in a wide variety of abdominal operations. Our purpose was to evaluate feasibility and safety of TAP bloc...
The Correlation between Knee Flexion Lower Range of Motion and Osgood-Schlatter's Syndrome among Adolescent Soccer Players
Aims: To evaluate the association between knee flexion range of motion (ROM) and Osgood-Schlatter syndrome among adolescent soccer players. Study Design: Observational case-control study. Methodology: A study group of 20...
A Purely Paraspinally Located Schwannoma from a Dorsal Root of a Spinal Nerve
Background: Spinal Schwannomas are benign nerve sheet tumors and the most common intradural extramedullary tumors of the spine, mainly occurring in the cervical and lumbar region. Case Description: Here we illustrate th...