Frequency of Hypothyroidism in Chronic Hepatitis C patients treated with Standard Interferon Therapy
Journal Title: Pakistan Biomedical Journal - Year 2018, Vol 1, Issue 2
Abstract
Chronic hepatitis C is a major health problem associated with high mortality and morbidity. It is the most common chronic hepatitis leading to chronic liver disease and hepatocellular carcinoma. One of the standard treatment used for hepatitis C is interferon therapy which can lead to thyroid dysfunction i.e. hyperthyroidism and hypothyroidism Objective: To assess the frequency of hypothyroidism in chronic hepatitis C patients treated with standard interferon therapy Methods: Thisdescriptive case series study was carried out at Outpatient Department of Medicine, King Edward Medical University/ Mayo Hospital Lahore for 06 months from January to June 2017. After ethical approval of the study, 200 patients of ages 15 to 65 years with both genders having chronic hepatitis C on Polymerase chain reaction (PCR) & normal thyroid functions test were taken by Non-probability, purposive sampling technique. Informed written consent was taken from all the patients. Serum thyroid stimulating hormone level (TSH) was sent to Centre for Nuclear Medicine (CENUM), Mayo Hospital Lahore before and after the completion of three months of interferon therapy and hypothyroidism was considered as TSH >4.0 mIU/L (normal range: 0.2-4.0 mIU/L) Results: The mean age of the patients was 36.29 + 8.5 years. Out of total 200 patients, 123 (61.5%) were males and 77 (38.5%) were females. At baselines mean TSH of the patients was 3.16 + 2.57 mIU/L. After 3 months of therapy 163 patients (81.5%) were euthyroid and 37 patients (18.5%) were having thyroid dysfunction. Among patients with thyroid dysfunction 29 (14.5%) were hypothyroid. Among hypothyroid patients 8 (27.6%) were males and 21 (72.4%) were females. The difference was statistically significant (P=0.0003) Conclusions: we concluded that large number of chronic hepatitis C patients develops hypothyroidism after getting standard interferon therapy and females are at more prone to develop hypothyroidism as compared to males.
Authors and Affiliations
Muhammad Farooq1*, Sami Ullah Mumtaz2, Hina Akhtar3, Kanza Ashraf1, Tayyeba Komal5, Irshad Hussain Qureshi6
Keywords
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- EP ID EP694170
- DOI https://doi.org/10.52229/pbmj.v1i2.46
- Views 155
- Downloads 0
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