Functional Links Between Glucocorticoids and Cytokines In DBA
Journal Title: Journal of Pediatrics & Child Care - Year 2015, Vol 1, Issue 1
Abstract
Diamond Blackfan anaemia (DBA) is a red blood cell aplasia characterized by erythropoietic defects as well as congenital anomalies. Forty percent of patients with DBA are treated with glucocorticoid steroids, which remain the mainstay of treatment in DBA. Many advances in the understanding of the physiological role of the glucocorticoid receptor have been made since the first introduction of glucocorticoids to the clinic, but their mechanism of action in the treatment of DBA is still under investigation. This review is intended to summarize the mechanism of glucocorticoid action specifically as related to erythropoiesis, focusing on the functional links between glucocorticoids and cytokines.
Authors and Affiliations
Yoan Konto-Ghiorghi
Keywords
Related Articles
- EP ID EP207645
- DOI 10.13188/2380-0534.1000001
- Views 114
- Downloads 0
Neonatal Hypotension, the Role of Hydrocortisone and Other Pharmacological Agents in its Management
Neonatal hypotension remains one of the most commonly encountered problems in neonatal intensive care units. Pharmacologic agents used in the management of neonatal hypotension include volume expanders, inotropes and vas...
A Boy with Disseminated Tuberculosis
Tuberculosis is a common infectious disease in developing countries. In the paediatric population, the disease can be manifested as pulmonary as well as extrapulmonary tuberculosis affecting multiple organs and systems a...
Preschool Developmental Screening with Denver II Test in Semi-Urban Areas
The first few years of life have a crucial role in development and provide a time window when a supportive and stimulating environment can be most effective, and conversely when adverse factors can cause more pervasive d...
Physical Exam and Historical Patient Factors Associated with Diagnosis of Pneumonia
Background: The use of chest radiography (CXR) to aid in the diagnosis of pneumonia varies among pediatric emergency physicians. Recent guidelines recommend clinical assessment to diagnose community-acquired pneumonia. O...
Intranasal Steroid and Asthma
A non randomized, active controlled trial was done and still is open to recruitment, open label, phase-1 type among few children over two years of age with positive history of atopy, WALRI & asthma, with intranasal stero...