Functional near-infrared spectroscopy on anhedonia in schizophrenia and major depressive disorder

Journal Title: Chinese Journal of Nervous and Mental Diseases - Year 2024, Vol 50, Issue 9

Abstract

[Objective] To explore the differences in brain activation related to anhedonia in patients with schizophrenia (SCZ) and major depressive disorder (MDD) during a verbal fluency task (VFT) based on functional near-infrared spectroscopy (fNIRS). [Methods] A total of 31 patients with first-episode SCZ, 45 patients with first-episode MDD and 45 healthy controls (HC) were included. The clinical symptoms were assessed using the 17-item Hamilton depression scale (HAMD-17), the positive and negative symptom scale (PANSS) and the Snaiss-Hamilton pleasure scale (SHAPS). All subjects completed the 48-channel fNIRS-VFT and the Chinese characters “Bai”, “Bei”, and “Da” were recorded in the VFT. The Homer2 software in Matlab was used to extract information of oxy-hemoglobin (Oxy-Hb) concentration during the task. [Results] In the fNIRS-VFT task, compared with HC, patients with SCZ had decreased Oxy-Hb concentration in the bilateral middle frontal gyrus, superior frontal gyrus, inferior frontal gyrus, right superior temporal gyrus, and left posterior cingulate gyrus (including 25 channels, P<0.05), compared with MDD patients, patients with SCZ exhibited significantly reduced Oxy-Hb concentration in the bilateral superior frontal gyrus, left middle frontal gyrus, and right superior temporal gyrus (including 6 channels, P<0.05). The results of the general linear model showed that SHAPS scores in the MDD group were negatively correlated with Oxy-Hb concentration in the right superior frontal gyrus (channels 26, 42) (β=-5.46, P=0.02; β=-5.01, P=0.01). [Conclusion] Patients with first-episode SCZ and those with first-episode MDD had functional abnormalities in bilateral middle frontal gyrus, and the left superior frontal, inferior frontal gyrus and postcentral gyrus. Additionally, abnormal activation of the right superior temporal gyrus and superior frontal gyrus was neurobiological markers of SCZ, abnormal activation of the right superior frontal gyrus was associated with anhedonia in MDD.

Authors and Affiliations

Yue WU, Mian LI, Hanxiaoran LI, Chuang XUE, Jinqi DING, Sugai. LIANG

Keywords

Related Articles

One case of adult onset neuronal nuclear inclusion body disease

This article reports a case of adult neuronal intranuclear inclusion body disease with clinical manifestations of tremor, cognitive decline, and binocular visual impairment, which has not been clearly diagnosed and treat...

A case report of COVID-19-associated acute necrotizing encephalopathy

This article reports one case of adult COVID-19-associated acute necrotizing encephalopathy (ANEC) .The patient developed disturbance of consciousness and seizure on the 12th day after SARS-CoV-2 infection. Imaging showe...

A case of propriospinal myoclonus with typical axial convulsions during sleep

Propriospinal myoclonus (PSM) is a rare painless movement disorder characterized by recurrent axial myoclonus during the wake and sleep transition periods. The recurrent muscle twitches during the hypnotic period severel...

Advance in research on EEG technology in non-suicidal self-injurious behaviour and suicidal ideation in depression

Non-suicidal self-injury behavior and suicidal ideation are important risk factors for suicide attempts in patients with depression. At present, studies have found that there are obvious differences in electroencephalogr...

a case of paraneoplastic cerebellar ataxia syndrome associated with immunocheckpoint inhibitor treated with Ofatumumab

A case of paraneoplastic cerebellar ataxia syndrome caused by immune checkpoint inhibitors (ICI) was treated with ofatumumab (OFA). The patient is a 57-year-old male. He used “Camrelizumab” immunotherapy for his previous...

Download PDF file
  • EP ID EP750546
  • DOI 10.3969/j.issn.1002-0152.2024.09.003
  • Views 28
  • Downloads 0

How To Cite

Yue WU, Mian LI, Hanxiaoran LI, Chuang XUE, Jinqi DING, Sugai. LIANG (2024). Functional near-infrared spectroscopy on anhedonia in schizophrenia and major depressive disorder. Chinese Journal of Nervous and Mental Diseases, 50(9), -. https://europub.co.uk./articles/-A-750546