FUNCTIONAL NEUROMARKERS OF POST-TRAUMATIC STRESS DISORDER (PTSD) IN A MAJOR ISCHEMIC STROKE SURVIVOR AFTER CAROTID ENDARTERECTOMY (CEA) REVASCULARIZATION
Journal Title: Acta Neuropsychologica - Year 2018, Vol 16, Issue 4
Abstract
The aim of this study was to test the hypothesis of developing Post-Traumatic Stress Disorder (PTSD) in a major right-hemisphere ischemic brain stroke survivor half a year after CEA revascularization, with the use of Event Related Potentials (ERPs). He was in a serious condition and had limited consciousness. Therefore, the doctor informed the patient's wife about the possibility of sudden death. The patient heard this information and remembered it, which was one of the main causes of the development of PTSD. On the basis of previous research amplitudes of P3 ERP, components elicited in the cued GO/NOGO tasks have been chosen as the candidate for PTSD neuromarkers .<br/><br/>A 44-year-old patient had a major ischemic brain stroke while sizeable atherosclerotic plaque causing critical stenosis of the internal carotid artery in Angio-CT was dioscovered. The patient was urgently operated on using CEA. After the operation he had the opportunity to see the removed plaque which had been the cause of his stroke. Despite the positive postoperative recovery, half a year later, the patient began to complain of flashbacks, anxiety, trouble in falling and staying asleep, difficulty in concentration, a loss of interest. For the diagnosis of PTSD we used Checklist Specific for a stressor (PCL-S). Additionally we used Checklist according to the Diagnostic Statistical Manual-5 (DSM-5) classification, and the patient met the PTSD criteria. The cognitive profile of the patient was measured with the use of the Wechsler Memory Test – III (WMS-III). Subsequently, the patient participated in the cued GO/NOGO task (Kropotov, 2009) with a recording 19-channel EEG. The P3 GO and NOGO waves in this task were found to be significantly smaller at p<0.01 in comparison to a group of healthy control subjects of the same age (N=23) taken from the Human Brain Institute (HBI) normative database (https://www.hbimed.com/). The pattern of this neuromarker in our patient corresponds to the ERPs pattern found in PTSD patients.<br/><br/>The ERPs in a GO/NOGO task can be used in the assessment of the functional brain changes induced by chronic PTSD.<br/><br/>
Authors and Affiliations
Mariusz Trystuła, Jolanta Góral-Półrola, Juri D. Kropotov, Maria Pąchalska
Keywords
Related Articles
- EP ID EP423539
- DOI 10.5604/01.3001.0012.8119
- Views 112
- Downloads 0
CHANGES OF MOOD AND ATTENTION DIVISIBILITY IN ROWERS EXPOSED TO HIGH-INTENSITY TRAINING
Higher probability of succeeding in competitive sports is to a large extent associated with psychological preparation. Emotional and cognitive functioning are important factors that can modulate the attitude of c...
EVENT-RELATED POTENTIAL STUDIES OF COMBINED MILD TRAUMATIC BRAIN INJURY/POST-TRAUMATIC STRESS DISORDER IN A RETIRED POLISH ARMY LIEUTENANT COLONEL
Background: The extensive Medline search performed allowed us to state that the majority of reports support evidence of information processing abnormalities in patients with Mild Traumatic Brain Injury/Post-Traumatic Str...
QUALITY OF LIFE IN APHASIA COMMUNITY GROUP MEMBERS: A SOCIAL MODEL OF CLINICAL TREATMENT
The purpose of this article is to provide speech-language pathologists with information about aphasia community group outcomes, with a focus on quality of life (QoL) factors. This article will also describe the soci...
A REHABILITATION PROGRAM AND SELECTED TREATMENT METHODS FOR A CHILD SUFFERING FROM AGENESIS OF THE CORPUS CALLOSUM
Children suffering from ACC, in the course of their development and growth, do not enjoy the same developmental chances as the healthy ones. Therefore the rehabilitation cannot be a series of accidental actions s...
AN INTEGRATED MODEL BASED ON THE QEEG INDEX, AGE AND COGNITIVE FUNCTION FOR CORTISOL LEVEL ESTIMATION IN ELDERLY PEOPLE
Cortisol is known to be correlated with cognition, aging, and quantitative electroencephalography (QEEG), although these factors have not yet been reported. This study aimed to evaluate an integrated model for estimating...