Fungal Keratitis – Epidemiology and Treatment Outcome - In North Costal Andhra Pradesh
Journal Title: Journal of Medical Science And clinical Research - Year 2017, Vol 5, Issue 5
Abstract
Purpose: To review the distribution, current trends, and response patterns for treatment of fungal keratitis isolates in costal districts over the last 2 years Methods Design: Retrospective, observational, case series. Participants: Microbiology records of suspected fungal keratitis cases that underwent a diagnostic corneal scraping and cultures from March 1,2010, through April 31, 2012,at sankar foundation eye hospital, teritiary eye care and referral center, were reviewed. Culture results and medical and surgical management response were reviewed and analyzed. Results: A total of 450corneal scrapings were taken during the 2years of the study. Pathogen was recovered in 380 samples (84.4%), with fungal keratitis accounting for 350 of the positive cultures (81.5%). Asperigillus 48.15%, Fusarium 43.15%, Yeast 0.2%, Paecillomysis0.52%, and Acremonium 0.52%, not able to grow in 7.63%. Out of 380 cases 315 cases responded for topical antifungals, 75 cases with deep infiltrates and endoexudates resistant to topical medication alone, 33cases posted for TPK , 42cases treated with intracameral Ampho-B 10-15 u and intrastromal 7.5microns at least 2-3 times along with oral anti fungals. Conclusions: 1. About 90% h/o of injury with vegetable matter,2.Pts who presented early are responded very well with Natamycin 5%e/d and Fluconazole e/d along with repeated superficial debridement . If not responding addition of Amphotericin B 0.2%e/d hrly is with good results, 3.Deep infiltrates and endoexudate cases those who were given intracameral and intra stromal along with oral azoles doing well than TPK patients after optical PKP. 6. Topical Voriconazole 20% e/d (aurolab) did not give any added advantage except in few cases. 7.Pts on steroids were refractory to maximum medical treatment ultimately going for surgical intervention.
Authors and Affiliations
Dr Veena. P
Keywords
Related Articles
- EP ID EP285276
- DOI -
- Views 78
- Downloads 0
Early Detection of Cirrhotic Cardiomyopathy Using Cardiac Bio-Markers: A Cross Sectional Study
Introduction: Cirrhosis is well known to be associated with severe hemodynamic changes like hyperdynamic circulation, increased cardiac output, increased heart rate and decreased systemic vascular resistance resulting in...
Histopathological Study of Colorectal Carcinomas
Introduction: Colorectal carcinoma ranks the fourth most frequent cancers in men and third in women which causes significant mortality and morbidity. Studies have shown increasing trend in incidence in India. Chronic inf...
Assessment of Obesity and Factors Responsible for Obesity among School Going Children
Purpose: Overweight and obesity is confined not only to adults but also being reported among children and adolescents. This study was done to evaluate the prevalence of obesity and Factors associated to it in school goin...
Effect of Qurs-e-Rewand (A Hepatoprotective Unani Formulation) on Pentobarbitone induced Sleeping in Mice
Background: The present study was planned to investigate the effect of Qurse Rewand commonly used compound hepatoprotective drug on sleep duration in sodium pentobarbital (PB)-induced sleeping in mice. Methodology: The a...
To Study the Prevalence of Non-Alcoholic Fatty Liver Disease in Type 2 Diabetes and to Correlate it with Lipid profile and Glycated Hemoglobin in a Hospital
As incidence of diabetes is continuously increasing in india and diabetic dyslipidemia is a leading cause of non Alcoholic fatty liver disease which may progress to cirrhosis and hepatocellular carcinoma. No proven treat...