Gastroretentive drug delivery system therapeutic management of peptic ulcer in geriatric patient
Journal Title: World Journal of Pharmaceutical Sciences - Year 2018, Vol 6, Issue 11
Abstract
A peptic ulcer, stomach ulcer, or gastric ulcer, also known as peptic ulcer disease, is a very common chronic disorder of the stomach which is mainly caused by damage or impairment of the stomach lining. Various factors such as pepsin, gastric acid, H. pylori, NSAIDs, prostaglandins, mucus, bicarbonate, and blood flow to mucosa play an important role in causing peptic ulcers. In this review article, our main focus is on some important gastroretentive drug delivery systems (GRDDS) (floating, bioadhesive, high density, swellable, raft forming, superporous hydrogel, and magnetic systems) which will be helpful in gastroretention of different dosage forms for treatment of peptic ulcer. GRDDS provides a mean for controlled release of compounds that are absorbed by active transport in the upper intestine. It also enables controlled delivery for paracellularly absorbed drugs without a decrease in bioavailability. The above approaches are specific for targeting and leading to a marked improvement in the quality of life for a large number of patients. In the future, it is expected that they will become of growing significance, finally leading to improved efficiencies of various types of pharmacotherapies.
Authors and Affiliations
Kajal A. Prajapati
Keywords
Related Articles
- EP ID EP506503
- DOI -
- Views 124
- Downloads 0
Analysis of test requisitions and optimum utilization of routine laboratory investigation in a tertiary care teaching hospital
Background: Overutilization of investigations, leads not only to excessive burden on the laboratory but also gives rise to a multitude of problems in patient management. Practice of evidence based laboratory medicine and...
Reiterate and integrate the adverse effect of antipsychotic agent and its attenuation by Ginkgo Biloba Extract on reproductive system and functions of rodents
The psychotic drug agents are linked and believed to increase risk of sexual dysfunction by increasing prolactin levels. Ginkgo Biloba Extract (GBE) is reported much effected in treating antidepressant induce sexual dysf...
Anti-tubercular drugs induced hepatotoxicity in patient with miliary tuberculosis: A case study
Miliary tuberculosis is also called pulmonary TB because of the innumerable tiny spots that form in the lungs is the size of millet, the small round seeds in bird food. Miliary tuberculosis may affect one organ or severa...
Effect of the polyherbal cream of Andrographis paniculata and Vernonia amygdalina in Truama wound
To evaluate the wound healing benefits of Andrographis paniculata (AP) and Vernonia amygdalina (VA) as a poly-herbal cream, using shear butter as the oil phase. Excision wound was inflicted on Wistar albino rats which we...
Gastroretentive drug delivery system therapeutic management of peptic ulcer in geriatric patient
A peptic ulcer, stomach ulcer, or gastric ulcer, also known as peptic ulcer disease, is a very common chronic disorder of the stomach which is mainly caused by damage or impairment of the stomach lining. Various factors...