GC/MS Analysis of Alkaloids in Galanthus fosteri Baker and Determination of Its Anticholinesterase Activity
Journal Title: Turkish Journal of Pharmaceutical Sciences - Year 2020, Vol 17, Issue 1
Abstract
Objectives: Amaryllidaceae alkaloids are well known for their wide range of pharmacological activities. Galanthamine, an Amaryllidaceae alkaloid, is an effective, selective, reversible, and competitive cholinesterase inhibitor marketed under different commercial names in several countries for the treatment of Alzheimer’s disease. The aim of this work was to study the alkaloid profiles of the aerial parts and bulbs of both flowering and fruiting periods of Galanthus fosteri Baker (Amaryllidaceae), as well as analyzing their inhibitory activities on both acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) for the first time. Materials and Methods: The alkaloid profiles of the four samples were determined by means of gas chromatography-mass spectrometry, and AChE and BuChE inhibition assays were performed by the modified Ellman method. Results: Totally, 22 compounds with mass spectral characteristics of Amaryllidaceae alkaloids were detected in the extracts. Significant AChE and BuChE inhibitory activities were observed in the tested samples (IC50 between 0.189 and 91.23 μg/mL). Conclusion: This study shows that G. fosteri, collected from Akdağ, Amasya (Turkey), is a potential source of diverse chemical structures of Amaryllidaceae alkaloids with cholinesterase inhibitory properties.
Authors and Affiliations
Ahmet EMİR, Ceren EMİR, Buket BOZKURT, Nehir ÜNVER SOMER
Keywords
Related Articles
- EP ID EP684727
- DOI 10.4274/tjps.galenos.2018.26056
- Views 168
- Downloads 0
Determination of Potential Drug–Drug Interactions Using Various Software Programs in a Community Pharmacy Setting
Objectives: The aim of the present study was to compare various software programs in detecting potential drug–drug interactions in a community pharmacy setting. Materials and Methods: Details of prescriptions were colle...
Levocetirizine Dihydrochloride-Loaded Chitosan Nanoparticles: Formulation and In Vitro Evaluation
Objectives: The aim of the present study was to formulate levocetirizine hydrochloride (LCD)-loaded chitosan nanoparticles at submicron level with high entrapment efficiency and prolonged effect for optimizing the plasma...
In Vitro Studies of Jatropha curcas L. Latex Spray Formulation for Wound Healing Applications
Objectives: There is an increasing demand for wound healing products of natural origin. Our objective was to develop a spray formulation from Jatropha curcas (J. curcas) L. latex extracts for wound healing applications....
Subchronic Toxicity Assessment of Orally Administered Methanol (70%) Seed Extract of Abrus precatorius L. in Wistar Albino Rats
Objectives: Abrus precatorius L. is a famous medicinal plant of the family Fabaceae and is widely used in traditional medicine for the treatment of various ailments. However, there are limited toxicological data availabl...
Effect of Probucol on Proliferation of Leukemia, Multiple Myeloma, Lymphoma, and Fibroblast Cells
Objectives: Probucol is a bisphenol antioxidant with antiinflammatory, antilipidemic and antidiabetic effect. Development and progression of cancer is closely related to chronic inflammation and oxidative stress. Agents...