GDF11 alleviates the formation of aortic aneurysm by reducing inflammatory responses
Journal Title: Journal of Air Force Medical University - Year 2023, Vol 44, Issue 8
Abstract
Objective To investigate the protective effect of GDF11 on the formation of aortic aneurysm and its effect on inflammatory responses. Methods Sixty 3-week-old male C57BL / 6 mice (10 13 g) were randomly divided into three groups: normal control group (n = 20), aneurysm group (n =20) and aneurysm and GDF11 co-treatment group (n =20). A mouse aneurysm model was constructed with β-aminopropionitrile (BAPN) drinking water, at a dose of 1 g· kg - 1· d - 1. The diameter of aortic vessels, GDF11 and MMP9 protein expression and experession levels of inflammatory factors were detected after 4 weeks. Results After feeding with BAPN, the diameter of aortic vessels enlarged, GDF11 protein expression decreased, while MMP9 protein expression and expression levels of inflammatory factors increased. GDF11 could significantly alleviate the enlargement of aortic diameter, and down-regulate MMP9 protein expression and expression levels of inflammatory factors ( P < 0. 01). Conclusion GDF11 co-treatment can significantly alleviate aortic vasodilation and reduce aortic vascular inflammation.
Authors and Affiliations
XUE Chao, LI Buying, JIANG Liqing, WANG Weiguang, JIN Zhenxiao, DUAN Weixun, REN Kai
Keywords
Related Articles
- EP ID EP724930
- DOI -
- Views 35
- Downloads 0
Effects of enhanced recovery after surgery clinical pathways on the outcomes of orthognathic surgery: a retrospective study
Objective To explore the effects of enhanced recovery after surgery (ERAS) clinical pathways on the postoperative outcomes of orthognathic surgery (OS) patients, including postoperative hospital stay, patient satisfacti...
Attention deficit hyperactivity disorder-like behavior induced by hypoxia in mice and its synaptic damage mechanism
Objective To explore the attention deficit hyperactivity disorder ( ADHD)-like behavior induced by hypoxia in mice and its synaptic damage mechanism. Methods The 3-week-old C57BL / 6 male mice were randomly divided int...
Research on HLA-A∗ 02 restricted CD8 + T cell immune responses in recovered individuals with COVID-19
Objective To investigate the HLA-A∗ 02 restricted severe acute respiratory syndrome coronavirus 2 (SARSCoV-2) epitope-specific CD8 + T cell responses in peripheral blood of individuals infected with SARS-CoV-2 after 4 5...
Protective effect of pentoxifylline on human umbilical vein endothelial cell injury induced by tert-butyl hydroperoxide
Objective To investigate the protective effect of pentoxifylline (PTX) on oxidative stress and mitochondrial function in human umbilical vein endothelial cells (HUVECs) induced by tert-butyl hydroperoxide (t-BHP). Metho...
Correlation between ApoE gene polymorphism, Hcy and coronary heart disease in T2DM patients
Objective To analyze the correlation between apolipoprotein E (ApoE) gene polymorphism, homocysteine (Hcy) level and coronary heart disease ( CHD) in type 2 diabetes mellitus ( T2DM) patients. Methods A total of 134 T2...