Gemistocytic Glioblastoma: A Case Report
Journal Title: World Journal of Pharmaceutical Sciences - Year 2017, Vol 5, Issue 7
Abstract
Introduction: Glioblastoma Multiforme (GBM) is the most common and lethal malignant primary brain tumor. It is classified by the World Health Organization (WHO) as a group of diffusely infiltrating astrocytoma, representing up to 50% of all primary brain gliomas, and carries the poorest prognosis. Aberrant genetic events and signaling pathways have clearly demonstrated that GBM is highly anaplastic and a morphologically high heterogeneous tumor. Method: We report a single case of Gemistocytic glioblastomas, in which a 46year male, presented with features of raised intracranial pressure and rapid neurological deterioration. The imaging findings were suggestive of high grade malignancy involving the brain. Results: This was confirmed as Gemistocytic glioblastoma after surgical excision and histopathological examination. Gemistocytic cells are large astrocytes with plump processes and massive accumulation of glial fibrillary acidic protein (gemistocyte). Their accumulation within astrocytoma may be due to BCL-2-mediated escape from apoptosis. Conclusion: In literature, exact incidence of these types of lesions is not known and it needs further evaluation. Understanding the genetic alterations, specific molecular biomarker and proliferative pathways may promote therapeutic development for the management of GBM.
Authors and Affiliations
Shruti Vimal
Keywords
Related Articles
- EP ID EP330281
- DOI -
- Views 82
- Downloads 0
Anti-inflammatory, Antimicrobial and Cytotoxic Activities of Essential Oil Extracted from Salvia officinalis L.
The aim of the study was to evaluate antimicrobial, antiinflammatory and cytotoxic activities of essential oil extracted from Salvia officinalis using chloroform as the solvent by Soxhlet apparatus. Total phenols and fla...
Flavocoxid Improves Bleomycin-Induced Respiratory Dysfunction and Pulmonary Fibrosis; In vitro Study
Pulmonary fibrosis; a progressive and fatal lung disorder is a common interstitial lung disease affecting millions of individuals worldwide with a mean survival time of about 3 years. It has been reported to be the most...
Role of spinal anaesthesia and general anaesthesia during laparoscopic cholecystectomy
Combining minimal invasive surgical and lesser invasive anesthesia technique reduces morbidity and mortality. The aim of the study is to compare spinal anesthesia with the gold standard general anesthesia for elective la...
Mouth Dissolving Tablets- A Review
Oral delivery is currently the gold standard in the pharmaceutical industry where it is regarded to be safe, economical, easy to form and the most important is the patient compliance. Other various dosage forms are also...
Status of over the counter buying and selling of antibiotics in Kathmandu Valley
Self-medication and irrational antibiotic prescribing are major factors in emergence of antibiotic resistance. This study finds incidences of self-medications in Kathmandu city. This descriptive, cross-sectional study wa...