Gender Differences in Characteristics of Colorectal Cancer Patients: Eight Years’ Experience in Tertiary Care Center.
Journal Title: The Egyptian Journal of Hospital Medicine - Year 2018, Vol 73, Issue 3
Abstract
<strong>Introduction and Objectives: </strong>Colorectal cancer (CRC) has become a very common researched topic in Saudi Arabia. Significance of the disease lay as the third most common cancer in the Kingdom plus the various risk factors it may be connected to. Smoking, obesity, age, and gender should be further investigated in our community to focus our screening and minimize the burden of this disease. We tried to determine the differences between males and females in term of demographic<strong>, </strong>clinical and treatment characteristics.<strong>Methodology</strong>: A retrospective cohort study was performed in all cases of CRC from 2006-2014 in King Abdulaziz Medical City in Riyadh, Kingdom of Saudi Arabia (KSA). Categorical data were presented as frequencies and percentages to summarize patients’ demographic data. Chi-square was used to compare between sex and the site of metastasis. Moreover, Cox regression was used to assess the risk factors on mortality.<strong> Results: </strong>Out of 581 patients diagnosed with colorectal cancer, 326 (56.51%) were males.The mean age of colorectal patients at the time of diagnosis was 59.7.Majority of the BMI was overweight 183 (37.0%) smoking history was found in only 18 (3.5%) patients. Most of the patients were stage IV. The bio marker (K-RAS) was done for 189 colorectal cancer patients, of which male and female patients had mostly wild type. Tumor marker Carcinoembryonic Antigen (CEA) showed that most of the patients were in the high range for male patients 140(48.8%) and for females 115(53.2%). <strong>Conclusion: </strong>No difference was found in regards to K-RAS mutation distribution by gender. High CEA was not associated to any age or gender. There was no statistical significance in relation to gender and response to treatment.
Authors and Affiliations
Eman Helal
Keywords
Related Articles
- EP ID EP584487
- DOI 10.12816/ejhm.2018.14357
- Views 123
- Downloads 0
Prevalence and Risk Factors of Dyspnea among General Population of Arar City, Kingdom Saudi Arabia
<span>Background: </span><span>Dyspnea is defined as the subjective experience of breathing discomfort. It is increasing by age and it is a common problem affecting up to half of patients admitted to acute, tertiary care...
Expression of micro RNA-9 in Patients with Acute Myeloid Leukemia and its Impact on Treatment Strategy
<span>Background: </span><span>Acute myeloid leukemia (AML) is a malignant disorder of hematopoietic tissue. It is one of the most common malignancies in adults. It is characterized by its heterogeneous and complex natur...
Complications Following Inhaled Anesthetics Administration: A Systematic Review of Current Literature
<strong>Background: </strong>anesthesia and sedation are an essential part of surgical operations and treatment in the intensive care unit. Sedation in the ICU is essential to keep patients well while they are intubated,...
Pharmacist’s Knowledge, Practice and Attitudes Toward Pharmacovigilance and Adverse Drug Reactions
<strong>Background: </strong>It is observed that the adverse drug reactions are one of the many reasons contributing in the deterioration of health and wellbeing. <strong>Objectives: </strong>This study was carried out t...
Prophylactic Oral Nifedipine to Reduce Preterm Delivery: A Randomized Controlled Trial in Women at High Risk
<span>Objective: </span><span>to evaluate </span><span>the efficacy of prophylactic nifedipine versus placebo in reducing spontaneous preterm delivery in asymptomatic women at high risk for preterm delivery.<br /> </span...