Gene Polymorphisms of Cytokines IFN γ +874 (A/T), TNF Α-308 (G/A), IL-6 -174 (G/C), L’il-10 -1082(A/G), -819 (C/T) -592 (C/A), TGF-β1 +869 (T /C), +915 (G/C) in Algerian Type 1 Diabetes and Latent Autoimmune Diabetes in Adults (LADA)
Journal Title: Journal of Diabetes and Obesity - Year 2017, Vol 4, Issue 2
Abstract
Background: We aimed to investigate the association between five cytokines IFN gamma 874 A T TNF Alpha -308 G A IL-6 -174 G C L rsquo il-10 -1082 A G -819 C T -592 C A TGF- beta 1 869 T C 915 G C and patients with type 1 diabetes T1D and Latent Autoimmune Diabetes in Adults LADA. Methods: Polymorphisms of cytokine were determined using the Sequence Specific Primers method PCR-SSP in 50 patients and 74 controls. Results: The results showed significantly higher frequency of IFN gamma 874 TA genotype 65 38 vs 45 95 pc 0 046 in T1D vs controls While T allele 56 25 vs 35 14 in LADA vs controls While significantly higher frequency of TNF gamma -308G A A allele 26 92 vs 13 51 in T1D vs controls and significantly higher frequency of GA Genotype 41 6 vs 24 32 in LADA vs controls While the results showed significantly higher frequency of IL-10 -1082 A G G A genotype 65 38 vs 45 95 in T1D and LADA versus control and IL-10 -592 C A C allele 84 vs 68 92 Regarding polymorphisms of IL-6 no significant difference was observed between T1D LADA and controls. Conclusion: These results suggest that the secretion low of IFN- gamma and high secretion of TNF- alpha may play an important role in protection and susceptibility to autoimmune diabetes in the Algerian population
Authors and Affiliations
Rachida Raache
Keywords
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- EP ID EP417861
- DOI 10.15436/2376-0494.17.1566
- Views 89
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