GENETIC ASPECT OF FAMILIAL OSTEOARTHRITIS REVIEW OF LITERATURE
Journal Title: WORLD JOURNAL PHARMACY AND PHARMACEUTICAL SCIENCE - Year 2017, Vol 6, Issue 6
Abstract
Osteoarthritis (OA) is the most common form of arthritis and is a leading cause of pain and disability worldwide. There is thought to be an important genetic component to the development of OA. In this review article, the methods used to study the genetics of OA are discussed, along with the main findings from these analyses, with a particular focus on the results of genome-wide association scans (GWAS). Functional validation of the results from genetic studies of OA is also described to put the genetic results into a biological context and show their relevance to the mechanisms involved in the development and progression of OA. The clinical relevance of the genetic findings to date is also discussed, as well as the research, which is still needed in this field to further improve the understanding of OA pathogenesis.
Authors and Affiliations
Saleh Abdulaziz Alkhulaifi
Keywords
Related Articles
- EP ID EP618267
- DOI -
- Views 161
- Downloads 0
PHYSICAL AND ANALYTICAL EVALUATION OF DIFFERENT BRANDS OF DIAZEPAM 5 MG TABLET AVAILABLE IN BANGLADESH
A major concern to the pharmaceutical industries is the quality of pharmaceutical finished dosage forms. The development of any pharmaceutical product is to maintain the quality standard of the product which is an import...
LOW DENSITY LIPROPROTEIN CHOLESTEROL GOAL LEVELS IN CARDIOVASCULAR SECONDARY PREVENTION
The Scandinavian Simvastatin Survival Study showed that the reduction of low density lipoprotein (LDL) cholesterol levels diminished 30% all causes mortality in coronary heart disease (CHD) patients. Later trials with st...
A PHYTOCHEMICAL AND PHARMACOLOGICAL REVIEW ON PELTOPHORUM PTEROCARPUM (DC.) BAKER EX HEYNE
In spite of great advances of modern scientific medicine, traditional medicine is still the primary form of treating diseases of majority of people in developing countries including India.The widespread use of herbal rem...
SEMI-EMPIRICAL QUANTUM ANALYSIS OF METHOD 3 OF THE INTERACTION OF FENTANYL WITH OPIOID RECEPTORS μ, κ AND δ.
Fentanyl (FE) is a potent opioid analgesic its main therapeutic effects are analgesia and sedation, as well as physiological functions such as breathing, gastrointestinal transit and stress response, as well as endocrine...
ORAL GLUCOSE TOLERANCE TESTS WITH NON-BOILED AND BOILED MOMORDICA CHARANTIA FRUITS
Background: The fruits of Momordica charantia L. are considered to lower blood glucose levels and as such are consumed in the raw state in Bangladesh. The fruits are also consumed in the cooked form as a vegetable. Since...