Genetic evolution of α fetoprotein producing gastric cancer

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Genetic evolution of α fetoprotein producing gastric cancer

Journal Title: Clinical Molecular Pathology - Year 2003, Vol 56, Issue 12

Abstract

Nineteen cases of AFP-GC were identified in the archival pathology files of the pathology division, National Cancer Centre Research Institute and Hospital, Tokyo, Japan, and the department of pathology at Jikei University, School of Medicine, Tokyo, Japan. All the cases selected had been tested for the quality of DNA preservation for adequate and reproducible polymerase chain reaction (PCR) amplification. The samples came from 16 men and three women, whose ages ranged from 40 to 80 years, with a mean age of 61. All the patients showed raised serum AFP concentrations, ranging from 42 to 2177 000 ng/ml. All samples were formalin fixed, paraffin wax embedded tissue blocks from surgically resected tumours. The maximum diameter of the tumours ranged from 18 mm to 120 mm. The depth of tumour invasion was to the submucosa in one patient, muscularis propria in three, subserosa in five, and exposure to the serosal surface in 10. Lymph node metastases were detected in 14 patients. Histology of all the cases showed a complex mixture of ordinary tubular, tubulopapillary adenocarcinoma, poorly differentiated adenocarcinoma with medullary growth pattern, enteroblastic foci with tubular formation and clear cytoplasm, and areas of hepatoid differentiation with large polygonal cells with eosinophilic cytoplasm in solid or trabecular patterns. Periodic acid Schiff positive hyaline globules were frequently seen. In 11 cases, in addition to invasive foci, preinvasive intramucosal neoplastic foci were identified. Table 11 summarises the clinicopathological profiles.

Authors and Affiliations

H Fujii, K Ichikawa, T Takagaki, Y Nakanishi, M Ikegami, S Hirose, T Shimoda

Keywords

EP ID EP679626
DOI 10.1136/jcp.56.12.942
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