Genetic markers in HLA region to identify patients with tuberculosis risk, in RA subjects
Journal Title: International Journal of Clinical Rheumatology - Year 2019, Vol 14, Issue 1
Abstract
Objetive: To identify the patients with RA at highest risk of TB, prior to the use of biological therapy antiTNF. Method: We carried out a study of two phases considered three groups, in the first we performed a case and control study in the Hospital Juárez de México, in the second phase, the results of phase one were analyzed with those obtained in the group of patients identified with Poncet´s disease. We compared the classes I and II of the HLA of patients naïve to biologic treatment with healthy controls. Result: We have identified several candidate alleles that will help to advance the personalized treatment of RA that takes into account the genetic risk to develop TB, particularly the alleles B27 and DQB1*0301. Conclusion: Patients with RA have an increased risk to develop TB and severe complications derived from it. This infectious process is related to the use of biologic.
Authors and Affiliations
Gustavo Lugo Zamudio, Rosa Elda Barbosa Cobos, Dolores Delgado-Ochoa, Rodrigo Huerta-Gutiérrez, Julio Granados Arreola
Keywords
Related Articles
- EP ID EP614570
- DOI -
- Views 63
- Downloads 0
Synovial fluid level of vascular endothelial growth factor (VEGF) can predict functional status and radiological severity in patients with knee osteoarthritis (OA)
Aim of the work: Detection of serum and synovial fluid level of Vascular Endothelial Growth Factor (VEGF) in patients with knee osteoarthritis (OA) and to determine its relation to radiological severity and function stat...
PTPN22, CTLA4, FcγRIIa, FcγRIIIa and FcγRIIIb polymorphisms in Tunisian patients with systemic lupus erythematosus
Background: Pathogenesis of systemic lupus erythematosus (SLE) involves both T cell tolerance breakdown and pathogenic autoantibodies. Polymorphisms in T cell regulatory proteins (PTPN22 and CTLA-4) and IgG receptors (Fc...
Effect of curcuma xanthorrhiza suplementation in vitamin D3 administration towards proteinuria, serum anti-dsDNA and IL-17 levels on systemic lupus erythematosus (sle) patients with hypovitamin D
Background: Vitamin D is an immunomodulator that plays a role in immunoregulation. Curcumin is also a potential immunomodulator in several autoimmune diseases. Curcumin-vitamin D bonds in VDR have different positions, th...
Clinical case report: Unusual and severe psoriatic arthritis mutilans
Psoriatic Arthritis (PsA) is considered part of the spondyloarthritis group, which is present in up to 42% of individuals with psoriasis and up to 15% of patients with psoriasis may have undiagnosed PsA. Psoriatic arthri...
Lower ratings of pain intensity in older adults lead to underestimation of disease activity in patients with rheumatoid arthritis
Background: To investigate the influence of age on the components of the 28-joint Disease Activity Score (DAS28)-C-Reactive Protein (CRP) in patients with Rheumatoid Arthritis (RA) and whether DAS28-CRP can be equally in...