GENEXPERT - IS IT AN EXPERT IN DIAGNOSIS OF EXTRAPULMONARY TUBERCULOSIS?
Journal Title: Journal of Evidence Based Medicine and Healthcare - Year 2017, Vol 4, Issue 51
Abstract
BACKGROUND Six countries in Asia account for 60% of the total new tuberculosis cases occurring globally with India leading the count. India accounts for approximately 25% of global incidence of tuberculosis with almost 2 deaths every 3 minutes due to tuberculosis alone. GeneXpert is a comparatively newer diagnostic test for detecting Mycobacterium tuberculosis complex, which uses the PCR to test specimens and simultaneously detects resistance to rifampicin, thus allowing diagnosis of DR-TB within a couple of hours. The present study was conducted to find the sensitivity and specificity of GeneXpert in extrapulmonary samples (lymph node and pleural fluid) and compare the results with those of smear and AFB culture with an aim to provide rapid diagnostic test to patients with suspected extrapulmonary tuberculosis. MATERIALS AND METHODS A retrospective data analysis of reports of extrapulmonary samples (lymph node and pleural fluid) of 45 patients sent for AFB smear, GeneXpert and AFB culture during routine investigations were studied. RESULTS Sensitivity of GeneXpert in lymph node samples was found to be 94.12% and specificity was 30.77% with positive predictive value of 64% and negative predictive value of 80%. The sensitivity of GeneXpert in pleural fluid samples was found to be 60% with 100% specificity. The positive predictive value was 100% and negative predictive value was 83.33%. CONCLUSION The overall sensitivity of GeneXpert was 96.67% with specificity of 100%, positive predictive value of 100% and negative predictive value of 83.33%. Thus, it is a valuable test for diagnosing extrapulmonary tuberculosis at the earliest with an added advantage of detecting resistance for rifampicin.
Authors and Affiliations
Mitali Mukund Nayak, Himanshu Suresh Thakker, Ruhee Gotmare
Keywords
Related Articles
- EP ID EP220231
- DOI 10.18410/jebmh/2017/611
- Views 98
- Downloads 0
EFFECT OF INTRACUFF LIGNOCAINE VERSUS LIGNOCAINE WITH DEXAMETHASONE ON ENDOTRACHEAL TUBE INDUCED EMERGENCE PHENOMENA AFTER GENERAL ANAESTHESIA- COMPARATIVE STUDY
BACKGROUND Inflating the ETT cuff with local anaesthetic would allow diffusion locally to produce anaesthesia to the mucosa, thereby attenuating stimulation during extubation. Dexamethasone, a corticosteroid, has anti-in...
A CROSS SECTIONAL STUDY ON THE PROFILE OF FOOD ALLERGY AMONG PATIENTS WITH CHRONIC URTICARIA IN KERALA
BACKGROUND Skin allergy in the form of urticaria is commonly encountered. Food allergy is one of the common aetiologies responsible for this clinical situation. Identifying the offending allergens and avoidance is one of...
ROLE OF MAGNETIC RESONANCE IMAGING IN THE EVALUATION OF INTERNAL DERANGEMENT OF KNEE JOINT
BACKGROUND Knee injuries are very common due to sports and repetitive activities. Accurate evaluation of the knee injuries is very essential for the proper management and outcome. The objective of this study is to correl...
EVALUATION OF PAEDIATRIC SPINAL DYSRAPHISMS BY ULTRASONOGRAPHY AND MAGNETIC RESONANCE IMAGING
BACKGROUND Congenital malformations of spine and spinal cord are referred to as spinal dysraphisms. They are caused by incomplete closure of neural tube around third and fourth week of embryonic development. Spinal dysra...
A STUDY ON MORBIDITY PROFILE OF GERIATRIC PATIENTS ADMITTED IN INTERNAL MEDICINE DEPARTMENT OF TERTIARY CARE HOSPITAL IN SOUTH ASSAM, INDIA
BACKGROUND The age structure of the population in the developed countries has so evolved that the numbers of old people is continually on the increase. Worldwide by 2025, the number of elderly people is expected to rise...