Gigantic retroperitoneal leiomyosarcoma - case report
Journal Title: Współczesna Onkologia - Year 2007, Vol 11, Issue 2
Abstract
Retroperitoneal leiomyosarcomas are very rare malignant neoplasms. They are built up of smooth muscle cells. They can be found beyond the retroperitoneal space in the uterus, the stomach, the intestines, the blood vessel walls and the skin. This type of tumour grows slowly and gives no characteristic clinical symptoms. This results in late diagnosis, when they grow to a huge size. Retroperitoneal leiomyosarcomas are most frequently described in the literature in the fifth or sixth decade of life. There are no biochemical markers which could suggest the development of leiomyosarcoma. The basic diagnostic examination includes: ultrasound and computer tomography of the abdomen. The fundamental treatment of retroperitoneal leiomyosarcomas consists in aggressive surgical treatment – complete tumour resection. Large size of the tumour can make it difficult to perform radical surgery. In the case presented in this report, our team managed to remove a retroperitoneal leiomyosarcoma completely despite its huge mass and size (300x200 mm). Data from the literature indicate that a complete resection of the tumour is the most significant prognostic factor in the case of patients with retroperitoneal leiomyosarcoma. The efficacy of radiotherapy and chemotherapy has not been proved. The other unfavourable prognostic factor in the course of sarcomas is the age of the patient, below 50 years old. The patient presented in the report is a 31-year-old woman, which is associated with a worse prognosis. According to some authors, the size of the tumour is not significant for the fast recurrence of the disease, whereas others state that it is. The case was presented because of such a huge leiomyosarcoma being rarely found in the retroperitoneal space, the age of the patient and the asymptomatic course of the disease.
Authors and Affiliations
Jadwiga Snarska, Hady Razak Hady, Fabian Kamiński, Sławomir Dariusz Szajda, Dorota Werel, Lech Zimnoch, Andrzej Siemiątkowski
Keywords
Related Articles
- EP ID EP144419
- DOI -
- Views 71
- Downloads 0
VEGFR-2-receptor - target for anticancer therapy
Vascular endothelial growth factor (VEGF) is a potent mitogen that plays a key role in the growth and maintenance of vascular endothelial cells as well as in the development of new physiological and tumour blood vessels....
Evaluation of the quality of life in patients undergoing low anterior resection or abdominoperineal excision with no preoperative radiation therapy for rectal cancer
Colorectal cancer (CRC), the most common type of malignant neoplasm of the digestive tract is a serious and growing problem not only in Poland but also all over the world. Most frequently, CRC is localized in the rectum....
Depresja i lęk u chorych z nowotworami złośliwymi
Pacjenci ze stwierdzoną chorobą nowotworową narażeni są bardzo na wystąpienie lęku i depresji. Przyczyną są zarówno zmiany biologiczne, zachodzące w organizmie, jak i czynniki społeczne. Pomimo dużego rozpowszechnienia t...
cytostatic drugs and their carcinogenicity - occupation risk problem for healthcare workers
Many of cytostatic drugs have mutagenic, teratogenic and carcinogenic properties, with no threshold dose for those effects. These properties make up a potential risk for healthcare workers who are occupationally exposed...
Ocena skuteczności różnych metod radioterapii przerzutów raka płuca do mózgu
Rak płuca jest najczęściej spotykanym nowotworem złośliwym u mężczyzn – powoduje ok. 1/3 zachorowań i zgonów. Wśród kobiet rak płuca jest drugim co do częstotliwości występowania po raku piersi. Przerzuty do ośrodkowego...