GLUCOSE HOMEOSTATIC AND PANCREAS PROTECTIVE POTENTIAL OF TECOMELLA UNDULATA ROOT EXTRACT IN STREPTOZOTOCIN INDUCED DIABETIC RATS .
Journal Title: Asian Journal of Pharamceutical and Clinical Research - Year 2017, Vol 10, Issue 6
Abstract
Objective: The study was aimed to evaluate glucose homeostatic and pancreas protective potential of Tecomella undulata root extract in streptozotocin induced diabetic rats.Methods: The ethanolic root extract was prepared by following standard soxhlation methods. The experimental design was divided in to control and treated groups for 28 days of comparative experimental schedule. The body and organ weights, serum biochemistry, histo-pathology, hematology and toxicity profiles were assayed by following standard methods and protocols.Results: The treatment of ethanolic extract of root of T. undulata was significantly (p ≤ 0.001) reduced glucose levels at 7day, 14day, 21day and 28 days in comparison to standard drug of metformin. Correspondingly, lipid profile i.e. total cholesterol, HDL, VLDL, LDL and triglyceride were also altered significantly. Whereas, body and organs weight and hematological parameters were not shown significant changes. Subsequently, toxicity profile i.e. hepatic and renal parameters were remained under normal ranges. Corresponding, the treatment of ethanolic root extract caused normalcy of histoarchitecture of pancreas in comparison to standard drugs.Conclusion: The results of study illustrated that Tecomella undulata root extract possessing particular kind of phytocompounds which caused glucose homeostatic and pancreas protective potential in diabetic rats.
Authors and Affiliations
Kanwar Lal, Ashok Purohit, Heera Ram
Keywords
Related Articles
- EP ID EP605354
- DOI 10.22159/ajpcr.2017.v10i6.17997
- Views 116
- Downloads 0
DEVELOPMENT AND VALIDATION OF NEW STABILITY INDICATING REVERSED-PHASE HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY METHOD FOR SIMULTANEOUS DETERMINATION OF METFORMIN HYDROCHLORIDE AND ERTUGLIFLOZIN IN BULK AND PHARMACEUTICAL DOSAGE FORM
Objective: The present study deals with the development, validation, and application of simple, precise, and accurate high-performance liquid chromatography (HPLC) method for the simultaneous estimation of metformin hydr...
STUDY OF PANEL OF DIAGNOSTIC CARDIAC MARKERS FOR ACUTE MYOCARDIAL INFARCTION
Objectives: The aim of this study is to estimate the level of creatine kinase-myocardial band (CK-MB), C-reactive protein (CRP), and lactate dehydrogenase (LDH) biomarker in myocardial infarction (MI) (troponin T-positiv...
STABILITY-INDICATING REVERSE-PHASE HIGH- PERFORMANCE LIQUID CHROMATOGRAPHIC METHOD DEVELOPMENT FOR SIMULTANEOUS ESTIMATION OF SOFOSBUVIR AND DACLATASVIR IN PURE AND PHARMACEUTICAL FORMULATION
Objective: The objective of the study was to develop a novel, simple, sensitive, accurate, precise, and stability-indicating reverse-phase (RP) liquid chromatographic method for simultaneous estimation of sofosbuvir and...
DIFFERENTIAL EXPRESSION ANALYSIS OF KRUPPEL LIKE FACTORS 6 AND ANTAGONISTIC EFFECT STUDY OF CINNAMIC ACID - AN IN SILICO APPROACH
Objective: Krüppel-like factor 6 (KLF6) is the significant member of a DNA binding proteins which mainly involved in the transcriptional regulation as well various promising cellular processes such as cell proliferation...
DIFFERENCES VALUE OF BLOOD UREA NITROGEN AND CREATININE SERUM IN CERVICAL CANCER SQUAMOUS CELL STADIUM IIB-IIIB BEFORE AND AFTER CHEMOTHERAPY PACLITAXEL CISPLATIN FOR SIX CYCLE IN SANGLAH GENERAL HOSPITAL DENPASAR BALI
Objective: The combination of paclitaxel-cisplatin regimen is one of the chemotherapy regimens used at Sanglah General Hospital, Denpasar. Cisplatin is a potent chemotherapeutic agent, but the nephrotoxic effects of cisp...