Glycosylated Hemoglobin and Its Relation with Lipid Peroxidation in Type-2 Diabetes Mellitus
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2018, Vol 6, Issue 5
Abstract
Abstract: Despite massive research, association of glycosylated hemoglobin (HbA1c) with oxidative stress in type 2 diabetes mellitus (T2DM) is poorly understood and still needs further clarification. In addition, free radicals production has been found to be associated with altered glucose levels. The objective of present study was to investigate the relationship between HbA1c, hyperglycemia and lipid peroxidation in T2DM patients and compared it with non-diabetic healthy subjects. Fasting blood glucose levels, HbA1c and malondialdehyde (MDA) levels were estimated by using standard methods in 50 patients of T2DM as Group II and compared it with 50 age matched healthy controls (Group I). The values were expressed as Mean ± SD and data from patients and controls were compared using students‘t’ test. Result: MDA and HbA1c levels along with fasting blood sugar were significantly high (p<0.001) in patients group as compared to control. In addition, HbA1c levels were positively correlated with MDA (r=0.784) which revealed that oxidative stress had significant association with poor blood glucose management in T2DM. Conclusion: Thus, oxidative stress is associated with hyperglycemia and HbA1c in T2DM patients. Therefore, maintenance of normal glycemic profile, regular monitoring of HbA1c levels along with control on excessive free radical production will hopefully contribute to a more adequate management of T2DM.
Authors and Affiliations
Dr. Aisha, Jasvinder Kaur Gambhir, Saurabh Srivastava, Rahul Saxena
Keywords
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