Growth Factor Receptor Tyrosine Kinase Inhibitors in Non-small cell lung cancer
Journal Title: Indian Journal of Pharmaceutical and Biological Research - Year 2015, Vol 3, Issue 2
Abstract
Aberrant increased expression and activation of receptor tyrosine kinases occur frequently in human carcinomas. Several small molecules targeting receptor tyrosine kinases, which have crucial roles in the growth factor signaling that promote tumor progression in various malignancies, including non-small cell lung cancer (NSCLC), are currently in clinical development. Therapeutic strategies include inhibition of growth factor tyrosine kinase function. Drugs of this type include those that target the epidermal growth factor receptor tyrosine kinase, those that target vascular endothelial growth factor receptors tyrosine kinase and those that target anaplastic lymphoma receptor tyrosine kinase. In this review we first discuss the role of receptor tyrosine kinases in human malignancies, and focus on discussing the potential use of epidermal growth factor receptor tyrosine kinase inhibitors and the vascular endothelial growth factor receptors tyrosine kinase inhibitors in NSCLC. In addition, we discuss the contribution of growth factor receptor tyrosine kinase inhibitors to the clinically observed resistance, and toxicity.
Authors and Affiliations
Lawaly Maman Manzo| Department of Biochemistry, School of Life Science and Technology, China Pharmaceutical University, Nanjing 210009, P. R., China Laboratoire de Biochimie Clinique, Hopital National de Niamey, BP 238 Niamey, Niger, Moudirat Lawaly| Centre National de Traitement du Cancer, BP 238 Niamey, Niger, Lui YU| Department of Biochemistry, School of Life Science and Technology, China Pharmaceutical University, Nanjing 210009, P. R., China
Keywords
Related Articles
- EP ID EP15338
- DOI -
- Views 332
- Downloads 13
Bacteriostatic activity of con a lectin from Canavalia ensiformis
The aim of this work was to explore the therapeutic applications of Con A lectin from Canavalia ensiformis and to explore its antibacterial activity. Activity of lectin was quantified by their ability to agglutinate er...
Idiopathic granulomatous mastitis: a great diagnostic challenge
Idiopathic granulomatous mastitis is a rare chronic inflammatory lesion of breast which presents as a spectrum of diseases and is diagnosed only histological. It is often a diagnosis of exclusion in most of the cases....
Preliminary Study of Hyphomycetes of Central India
During the preliminary investigation of hyphomycetes from central India eight species of freshwater and freshwater-borne Hyphomycetes encountered in foam samples collected from the different streams and rivers. These fun...
Role of arbuscular mycorrhiza fungi on tolerance to salinity of the tree legume Albizia lebbeck (L.) inoculated by Rhizobium
Myrica esculenta (Myricaceae) and Syzygium cumini(Myrtaceae), the Indian traditional fruits The effect of different level of salinity on growth, nodulation and Nitrogen fixation of single and dual inoculated tree legum...
Biochemical analysis, pharmacological activity, antifungal activity and mineral analysis in methanolic extracts of Myrica esculenta and Syzygium cumini: the Indian traditional fruits growing in Uttarakhand Himalaya
Myrica esculenta (Myricaceae) and Syzygium cumini(Myrtaceae), the Indian traditional fruits were studied for their biochemical assay, antifungal activity and mineral analysis. The biochemical assay in terms of total phen...