Haematological and biochemical parameters of the F2 rats’ organism in a period of prolonged watering of nano-Ge citrate
Journal Title: Біологія тварин - Year 2017, Vol 19, Issue 3
Abstract
In the article the results of experimental studies of the impact of different tenfold (20 and 200 μg Ge) doses of Ge citrate, obtained by nanotechnology method, on hematological and biochemical profile of the organism of the F2 male rats of second offspring are shown. It was established that the use of nano-Ge citrate at doses 20 and 200 μg Ge/kg of body weight with drinking water during four months leads to decrease of red blood cell number in both groups of males and to decrease platelets only under action of 20 μg of Ge, with increase of monocytes in animals of this group compared to the control. The possibility of strengthening the deponation functions of the rat organism for erythrocytes and leukocytes under the actions of the Ge citrate were discussed. In the blood of males in the research groups an increase of the albumin, Ca, P, TAG were noted that indicates a stimulatory effect of Ge citrate on its transport function and supplying structural and energy elements for organs and systems. Under the action of nano-Ge citrate in the blood of males in research groups an influence of enzymatic link of the antioxidant support network grows with the increase of SOD and HP-activity and decrease of lipid peroxidation intensity. The applied doses of nano-Ge citrate promote an increase of immunophysiological reactivity of the males’ organisms with the increase of content of middle mass molecules, circulating immune complexes, sialic acid and ceruloplasmin in their blood compared to the concentration of these components in the blood of animals in the control group.
Authors and Affiliations
R. S. Fedoruk, U. I. Tesarivska, M. I. Khrabko, M. M. Tsap, O. P. Dolaychuk, S. I. Kropyvka
Keywords
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- EP ID EP292385
- DOI 10.15407/animbiol19.03.115
- Views 110
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