HAEMATOLOGICAL AND CYTOKINE PARAMETERS IN MALE ALBINO RATS ADMINISTERED ORALLY WITH SINGLE/COMBINED DOSES OF TRAMADOL/VIAGRA
Journal Title: European Journal of Biomedical and Pharmaceutical Sciences - Year 2018, Vol 5, Issue 9
Abstract
This study evaluated haematological and cytokine parameters in male albino rats administered orally with single/combined doses of tramadol/viagra. Twenty-two male albino rats (180-220g body weight) were grouped into 4 (n=6) administered orally with tramadol+viagra (6&4mg/220g.bwt), viagra (4mg/180g.bwt), tramadol (6mg/180g.bwt) and control (n=4) for 3weeks. Rats were sacrificed by cardiac puncture and 9ml of blood collected for analysis of haemoglobin concentration (Hb), Packed cell volume (PCV), Red blood cell (RBC) count, White blood cell (WBC) count, platelet count, interleukin 8 (IL-8) and interleukin 10 (IL-10) using Elabscience ELISA-kits. GraphPad Prism 5.03 software was used to analyze data generated. Haematological parameter analysed showed no statistically significant difference in the values for RBC count of the various treatment groups compared with control group (p>0.05). There was however, a statistically significant decrease Hb and PCV values across the various treatment groups compared with control group (p<0.05). A statistically significant increase was seen in WBC count in viagra, tramadol group, whereas a statistically significant decrease WBC was observed in tramadol+viagra group (P<0.05). Cytokine parameters showed no statistically significant difference in IL-8 in sildenafil, tramadol groups (p>0.05), significant decrease in IL-8 value of tramadol+viagra group compared with control (p<0.05). There was no statistically significant difference in IL-10 for tramadol+viagra, sildenafil groups compared with control (p>0.05) but a statistically significant increase was seen in the value of IL-10 for tramadol group (p<0.05). Daily use of single/combine doses of Tramadol, Viagra causes significant alterations in haematological, cytokine parameters. Thus, anaemic, cancer patients should be properly monitored to avoid the risk of aggravating their condition. There is need to evaluate the effects of these drugs on the haematological and cytokines parameters in humans.
Authors and Affiliations
Jacob Ransom Baribefii
Keywords
Related Articles
- EP ID EP638368
- DOI -
- Views 143
- Downloads 0
ASSOCIATION BETWEEN POLY CYSTIC OVARIES SYNDROME AND SERUM LEVEL OF CHROMIUM, ZINC AND MAGNESIUM
Background Polycystic ovary syndrome (PCOS), as the most prevalent endocrine disorder in reproductive-aged women, is associated with reproductive and metabolic abnormalities. Despite the large literature on the role of d...
SCREENING OF BIOLOGICAL ACTIVITIES OF ACACIA FARNESIANA (GUYABABLA), A MEDICINAL PLANT OF BANGLADESH
The crude methanol extract of bark of Acacia farnesiana (L.) Willd. as well as its hexane, carbon tetrachloride, chloroform and aqueous soluble partitionates were subjected to screening for total phenolic content, and cy...
DIVISION OF ALLELES IN THE DETERMINATION OF KINSHIP IN SMALL LOCAL POPULATIONS
In this study the efficacy of short tandem repetitive sequences - STR was examined to prove kinship among the descendants of one parent pairs within the small local population by analyzing sharing of alleles per locus at...
INTERFERING EFFECT OF BILIRUBIN ON THE MEASUREMENT OF ALKALINE PHOSPHATASE ACTIVITY
Introduction: Analytical interference is the systematic error of measurement caused by a sample component which does not by itself produce a signal in the measuring system. Objective: This study was designed to evaluate...
AMELIORATION EFFECT ON DIABETES BY ETHYL ACETATE AND METHANOL LEAF FRACTIONS OF Nauclea Latifolia IN ALLOXAN-INDUCED DIABETIC RATS
The antidiabetic effects of ethyl acetate and methanol fractions of Nauclea latifolia were investigated in alloxan induced diabetic rats. Fractions of Nauclea latifolia at the doses of 150 and 300mg/kg were administered...