Haematological Parameters in PLHIV with Utility of Absolute Lymphocyte Count (ALC) As Surrogate Marker for CD4 Count: A Study from India
Journal Title: Indian Journal of Pathology: Research and Practice - Year 2018, Vol 7, Issue 5
Abstract
Context: Since it’s first report in 1982, HIV has emerged as a major pandemic. Haematological abnormalities are among the most common clinicopathological manifestations of HIV infection including impaired haematopoiesis, immune mediated cytopenias and coagulopathies. Aims: To study haematological parameters in PLHIV and to correlate them with CD4 count. To correlate Absolute Lymphocyte Count (ALC) with CD4 count to evaluate the utility of ALC as a surrogate marker for CD4 count. Settings and Design: Prospective observational study Methods and Material: After obtaining informed consent, 225 PLHIV were clinically evaluated and subjected to CBC, PBS, ALC, ESR and CD4 count. Statistical analysis used: Data was expressed as percentage and mean±standard deviation. Statistical tests used were chi-square test, Fisher’s exact test and Mann-Whitney U test and Kolmogorov-smirnov analysis. Also, Pearson’s rank order correlation and ROC curve was used. Results: The important haematological findings noted were anaemia (n=123,54.6%), leucopenia(n=34,15.2%), lymphocytopenia (n=128,56.9%), thrombocytopenia (n=10,4.4%) and raised ESR (n=162,72%). CD4 count was reduced in 156 cases (69.3%). Haemoglobin, MCV, MCH and ALC (p<0.0001) showed significant positive correlation with CD4 count. ALC 1400cells/µl indicated CD4<200cells/µl. Conclusions: The most frequent haematological finding is lymphocytopenia followed by anaemia. Haemoglobin, MCV, MCH and ALC showed rise with increase in CD4 count. ALC 1400cells/µl can act as surrogate marker for CD4<200cells/µl in resource poor settings.
Authors and Affiliations
Singh Swati
Keywords
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- EP ID EP523146
- DOI 10.21088/ijprp.2278.148X.7518.21
- Views 90
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