Haematological Profile As A Screening Tool For Neonatal Sepsis : A Hospital Based Study
Journal Title: International Journal of Medical Science and Innovative Research (IJMSIR) - Year 2018, Vol 3, Issue 12
Abstract
Objective: The present study was undertaken to emphasize the role of hematological scoring system (HSS) in the early detection of neonatal sepsis. Material And Methods: The study enrolled 100 neonates admitted in nicu with clinical suspicion of sepsis. The detailed perinatal history was recorded. Blood sample was taken for routine blood count , Esr and crp along with peripheral smear for each patient which was analysed using haematological scoring system that included total leukocyte count, total polymorphonuclear neutrophils (PMN) count, elevated immature PMN count, elevated immature: Total (I:T) PMN ratio, immature: Mature (I:M) PMN ratio ≥0.3, platelet count ≤150,000/mm3 and pronounced degenerative or toxic changes in PMNs. Blood culture was taken as a standard test. Sensitivity, specificity, positive and negative predictive values (NPVs) were calculated for each parameter. Results: Out of the 100 infants,those in full blown sepsis were 40, probable sepsis category were 21 (n=21) and remaining were normal (n=39) asymptomatic.55% had positive blood culture. Of the total 46 (46%) were term and, 54 (54%) preterm.The study had 42(42%) males and 58 (58%) females. Maximum 57 (57%) neonates presented within the first 24 h of life. For sepsis and probable sepsis, I:T and I:M PMN ratio have highest sensitivity, specificity, positive predictive value and negative predictive value followed by total PMN count. Conclusion: Haematological profile is a simple, easy, cheap and quick adjunct for the diagnosis of clinically suspected cases of neonatal sepsis.
Authors and Affiliations
Dr Deepa Hatwal
Keywords
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