Haemorheologic And Biochemical Parameters Of Pre-Eclamptic Patients In University Of Calabar Teaching Hospital, Calabar, Nigeria
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2018, Vol 17, Issue 5
Abstract
Pre-eclampsia refers to pregnancy-induced hypertension, a condition characterized by diffuse maternal endothelial dysfunction and a systemic inflammatory response with possible haemorheological changes. This study assessed haemorheologic and biochemical parameters of thirty pre-eclamptic patients admitted in University of Calabar Teaching Hospital and compared same with those of thirty normal pregnant as well as thirty apparently healthy non-pregnant controls aged 18-45 years. Weight, height and blood pressure of subjects were measured using standard instruments while body mass index was calculated. Erythrocyte sedimentation rate, relative plasma viscosity and fibrinogen concentration were used to assess haemorheology while biochemical parameters included protein in urine, total protein, albumin, globulin and uric acid concentrations. All tests were performed using standard techniques. The systolic and diastolic blood pressures, body mass index, erythrocyte sedimentation rate, relative plasma viscosity, fibrinogen concentration, total protein, albumin, globulin and uric acid levels of the pre-eclamptic patients were significantly higher (p<0.05) than values obtained for normal pregnant and non-pregnant controls. Blood pressure correlated positively (r=0.071; r=0.362) with uric acid concentration and a directly proportional relationship was expressed between levels of protein in urine and uric acid concentration of pre-eclamptic patients. Fibrinogen concentration was significantly higher (p<0.05) in the third versus second trimesters for normal pregnant subjects. Gestational age had no significant effect on the measured parameters among pre-eclamptic patients. Altogether, significant changes in haemorheologic and biochemical parameters existed in pre-eclamptic condition with increased risk of developing thrombosis and other complications of hypercoagulation.
Authors and Affiliations
Stella B. Egbe, Euphoria C. Akwiwu, Patience A. Akpan, Josephine O. Akpotuzor
Keywords
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- EP ID EP375382
- DOI 10.9790/0853-1705141824.
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