harmacokinetics and bioavailability of difloxacin in camel
Journal Title: Journal of Veterinary Medical Research - Year 2005, Vol 15, Issue 2
Abstract
The pharmacokinetic profile of difloxacin was investigated in camels after single intravenous and intramuscular administration of 5 mg kg-1 b.wt. After i. v. injection, serum concentration time curve was best described as two compartment open model. The distribution and elimination half lives (t0.5 (') and t0.5())) were 0.513± 0.01 h and 6.3±0.15 h. respectively. Difloxacin was distributed extravascularly with a volume of distribution (Vdss) 1.10 ± 0.035 l kg-1., and total body clearance (CLB) of 0.141+ 0.031 l kg-1 h-1. following intramusclar injection, peak serum concentration (Cmax) 2.59 ± 0.19 ug ml-1 attained after Tmax 3.05 ± 0.035 h. The absorption and elimination half lives (t0.5 (ab) and t0.5 (el)) were 0.95 ± 0.003 and 5.86 ± 0.33 h., respectively. The systemic bioavailablility (F) and the plasma protein binding were 87.95 and 23 %, respectively.
Authors and Affiliations
M. A. Tohamy1; A. A. M. El- Gendy1; M. Ismail2 1Pharmacology Department, Faculty of Veterinary Medicine Beni-suef University, Beni-suef, Egypt 2Pharmacology Department, Faculty of Veterinary Medicine, Cairo University, Cairo, Egypt
Keywords
Related Articles
- EP ID EP682716
- DOI -
- Views 244
- Downloads 0
Light and electron microscopic studies on some lymph nodes of the adult one-humped camel (Camelus dromedarius)
Samples from medial retropharyngeal, superficial cervical and deep femoral lymph nodes of four camels were fixed in neutral buffered formalin and prepared for light and electron microscopic examination. The camel lymph n...
Effects of high dietary energy, with high and normal protein levels, on broiler performance and production characteristics
This study was conducted to investigate the effect of high metabolizable energy diets with normal or wide metabolizable energy to crude protein ratios (ME:CP) on the performance, carcass characteristics, body composition...
Studies on the Prevalence of Enterobacteriaceae in Chickens and Chicken eggs
This study was done to investigate the prevalence of the Enterobacteriaceae in chickens and eggs. Isolation of forty four different bacterial isolates belonging to Enterobacteriaceae from chicken egg samples, cloacal swa...
Preparation of inactivated canine distemper vaccine using different inactivators
Development of environmental, safe and protective vaccines against infectious pathogens remains a challenge. In consequence of its high morbidity and mortality rates canine distemper is one of the most important diseases...
effect of castration and docking of lambs on maintenance behaviour and cortisol level
Thirty apparently healthy lambs with average weight and age of 5.8±0.5 kg and 15±1.6 days respectively were chosen in Sids Agricultural Research Station belonging to Animal Production Research Institute in Beni-Suef gove...