Head and neck amyloidosis
Journal Title: Otolaryngologia Polska - Year 2008, Vol 62, Issue 5
Abstract
Introduction. Amyloid is a pathological protein which can accumulate in almost every tissue, consequently resulting in illness (amyloidosis). Amyloid has a red color when the slice preparation is stained with Congo red staining and under polarized light exhibits a characteristic apple-green color. Over 26 different proteins, that can form amyloid, have been described. AL, AA and ATTR amyloidosis are the most frequent type of amyloidosis. Head and neck is a rare region for amyloidosis, which can be localized and/or systemic. Early diagnosis and precise classifi cation of the amyloidosis is essential for treatment planning. Various treatment strategies: antinflammatory management, chemotherapy, immunotherapy, surgery, gene therapy, to name just a few, are already readily available or are currently being explored or researched. Material and methods. Three cases are presented here: an elderly women with tongue and neck tumor and two patients with laryngeal tumors. The biopsy of the lingual and laryngeal tumor and ultrasonography in the fi rst case have been performed in the ENT-Department and Ambulance. Results. In the Internal Medicine Department the patient with lingual and neck tumor, due to symptoms such as: swallowing disorders, dysartria, painful joints swelling and carpal syndrome in anamnesis, previously underwent an examination in order to rule out scleroderma. The investigation appeared to be negative. The histopathology investigation of the lingual tumor identified amyloidosis. USG has not revealed any signifi cant findings. The two patients with laryngeal tumor, except for hoarseness, has not manifested other symptoms suggesting general illness. The biopsy established that there was localized amyloidosis. Conclusion. Diagnosis of amyloidosis and its correct classifi cation continue to pose a great challenge. Two factors play a pivotal role in the identifi cation of local or systemic amyloidosis: the local and/or systemic manifestation and Congo red staining as a gold diagnostic standard.
Authors and Affiliations
Małgorzata Leszczyńska, Łukasz Borucki, Mariola Popko
Keywords
Related Articles
- EP ID EP51636
- DOI -
- Views 97
- Downloads 0
Endoscopic treatment of malignant tumors in the nose and paranasal sinuses
SUMMARY Malignant neoplasms of the nose and paranasal sinuses constitute about 3% of head and neck tumors. They are more often observed in males. We discuss clinical appearance and treatment performed in 6 individuals wi...
The assessment of correlation between mean arterial pressure and intraoperative bleeding during endoscopic sinus surgery in patients with low heart rate
Induced controlled hypotension is a standard method aimed at decreasing intraoperative bleeding and achieving good operative field conditions. Low hemodynamic parameters during the operation are related to increased risk...
Carcinoma of the Iarynx in Region of Warmia and Mazury (1998-2007): epidemiological and clinical analysis and assessment of treatment results
Evaluation results of treatment polyps of nose and paranasales sinuses by endoscopic method
Introduction. This work aimed at the analysis of results of the treatment of nasal and paranasal sinus polyps by the endoscopic method. Material and methods. The tests were conducted on 142 patients, including 75 women a...
Ocena skuteczności radioterapii niezaawansowanego raka krtani u chorych powyżej 70 roku życia
Evaluation of the results of radiotherapy in elderly patients with early laryngeal cancer, the relation between comorbidities and the overall treatment time, and the influence of treatment interruptions on the outcome of...