HEALTH-RELATED QUALITY OF LIFE IN CHILDREN WITH SEVERE HEMOPHILIA A IN UKRAINE: AGE-RELATED FEATURES ON THE INFLUENCE OF THE SUBSTITUTION TREATMENT METHODS
Journal Title: INTERNATIONAL ACADEMY JOURNAL "Web of Scholar" - Year 2018, Vol 2, Issue 7
Abstract
Objective: study the influence of the substitution treatment methods on the health-related quality of life (HRQoL) in children with severe hemophilia А (HА) in different age groups. Materials and methods: HRQoL is examined in 105 children of three age groups (Group І (n=31) – children 4-7 years, ІІ (n=46) – 8-12 years, ІІІ (n=28) – 13-16 years) with HA using Haemo-QoL questionnaire. The indicators of HRQoL were compared between different age groups, undergoing Prophylaxis Treatment (PT), Treatment “On-demand” (OD) and ІТІ (immune tolerance induction) therapy. Results: The worst HRQoL in children of all groups is manifested in the course of ІТІ. When comparing HRQoL in the course of PT and OD it was found that in Group І the best HRQoL is in the course of OD, in Group ІІ it does not differ, while in Group ІІІ in the course of PT general HRQoL is the best, but such a difference was not statistically significant (SS), at SS the comparison of HRQoL of the most part of segments of psycho-social functioning. Conclusions: it was proved that HRQoL in children with HA depends on the treatment method with age-related features of such dependence.
Authors and Affiliations
A. I. Markin, L. Ya. Dubey
Keywords
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- EP ID EP396882
- DOI 10.31435/rsglobal_wos/12072018/5983
- Views 159
- Downloads 0
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