Helicobacter Pylori have positive association in developing peptic ulcers in patients with chronic liver diseases-an experience from Eastern India.
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2018, Vol 17, Issue 1
Abstract
H .pylori infection is commonly associated with Peptic Ulcer Disease (PUD). Role of H. pylori in the development of peptic ulcers with Chronic Liver Disease (CLD) is still not clear. The aim of this study is to find out the prevalence of H. pylori infection among the CLD patients and to identify its relationship in development of peptic ulcer among CLD patients. 60 patients were enrolled from Out Patient Department (OPD) of Medical Gastroenterology in a tertiary care hospital, Kolkata. All patients underwent blood tests to evaluate the liver chemistry. To establish the etiology of chronic liver disease, various biochemical parameters were examined. To find presence of peptic ulcer upper gastrointestinal endoscopy, ultrasonography was conducted. For H.pylori infection, Rapid Urease Test (RUT) and serum IgG for H. pylori were conducted. Active peptic ulcers were detected in 15% among study subjects. Among them, 55.5% tested positive for H. pylori where as among non peptic ulcer subjects, 3.9% tested positive for Helicobacter pylori and the difference was statistically significant (p<.001).The prevalence of peptic ulcer according to UGI endoscope was 15% among patients with CLD, found higher than previous studies. The higher statistically significant prevalence of H. pylori infection among CLD patients with peptic ulcer than without peptic ulcer was also supported by different previous studies done in different settings. This study revealed that there was more prevalence of H. pylori infection in peptic ulcers cases among the CLD patients which is statistically significant.
Authors and Affiliations
Dr. Kalidas Biswas1 ,, Dr. Arup Chakraborty2
Keywords
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- EP ID EP365970
- DOI 10.9790/0853-1703024753
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