Hematological and liver toxicity of anti-tuberculosis drugs
Journal Title: Electronic Physician - Year 2016, Vol 8, Issue 9
Abstract
INTRODUCTION: Tuberculosis (TB) is a major global health problem, and anti-tuberculosis drugs can cause severe adverse reactions. The aim of this study was to determine hematological and biochemical changes and associated risk factors in smear positive pulmonary tuberculosis patients undergoing treatment with standard protocols. METHODS: In a descriptive study, a total of 40 tuberculosis patients aged between 15-60 years were collected from hospitals in Khuzestan Province (Iran) from March 2013 to March 2014. The patients were treated with drugs (isoniazid, rifampicin, ethambutol, and pyrazinamide) during the initial two months, followed by isoniazid and rifampicin for the next four to six months. Activities of liver enzymes (ALT, AST, and ALP) and hematological parameters were recorded before and after treatment. Data were analyzed using paired samples t-test and Wilcoxon test by SPSS 16. RESULTS: After using drug treatments, hematological parameters (RBC, Hb, HCT, MCV, MCH, and MCHC), except platelet count, were changed significantly (p ≤ 0.001). Liver enzyme activities (ALT, AST, and ALP) were decreased significantly (p ≤ 0.001) after treatment. CONCLUSION: In this study, changes of hematological and biochemical parameters have been observed in patients with pulmonary tuberculosis. It can be concluded that the anti-tuberculosis treatment is associated with changes of hematological parameters and liver enzymes
Authors and Affiliations
Mirlohi MS, Ekrami A, Shirali S, Ghobeishavi M, Pourmotahari F
Keywords
Related Articles
- EP ID EP331619
- DOI 10.19082/3010
- Views 96
- Downloads 0
Investigation of Occupational Stress and its Relationship with the Demographic Characteristics of Workers in Ilam, Iran
Introduction: Workers are more susceptible to stress disorder for several reasons. The aim of this study was to investigate occupational stress among workers and other personnel at the ZardjinBaft Workshop in Ilam, Iran,...
The association between death anxiety with spiritual experiences and life satisfaction in elderly people
INTRODUCTION: Death anxiety is a concept with greater importance among the elderly as they approach inevitability of death. Identifying the correlates of death anxiety among old people is important in order to reduce the...
Analysis and Modeling of Threatening Factors of Workforce's Health in Large-Scale Workplaces: Comparison of Four-Fitting Methods to select optimum technique.
Workforce is one of the pillars of development in any country. Therefore, the workforce's health is very important, and analyzing its threatening factors is one of the fundamental steps for health planning. This study wa...
Perceptions of teenage women about marriage in adolescence in an Iranian setting: A qualitative study
BACKGROUND AND AIM: Early marriage threatens the health and human rights of millions of girls all around the world. The aim of this study was to explore the perceptions of Iranian teenage women about marriage in adolesce...
Cognitive emotional consequences of male infertility in their female partners: a qualitative content analysis.
Infertility, as a global phenomenon and one of the most important issues of reproductive health, affects women more often than men, even when the infertility is due to a male factor. The purpose of this study was to expl...