Hemodynamic properties and respiratory efforts: A comparative study between etomidate and propofol
Journal Title: Medpulse International Journal of Anesthesiology - Year 2019, Vol 9, Issue 2
Abstract
Background: A successful general anaesthesia is defined as a reversible triad of hypnosis, analgesia and abolition of reflex activity. Over years, there has been a continuous search for better and safer intravenous agent. Presently etomidate and propofol are popular, rapid acting and safe induction agent, however these two drugs have different induction characteristics. Objectives: To compare the hemodynamic parameters and respiratory efforts between etomidate and propofol. Methodology: In this prospective randomized double blinded study, we studied 60 patients randomly allocated into either group P (propofol group) or to group E (Etomidate group) of 30 each. All patients premedicated with inj. midazolam 0.02mg/kg IV, inj. Fentanyl 2 microgm/kg IV. Group P received propofol infusion at 0.5 mg/kg/hr and group E at 0.05mg/kg/hr until BIS value dropped to 50. Then patients were intubated with vecuronium 0.1mg/kg and anaesthesia maintained according to institutional protocol followed by extubation after adequate recovery. Hemodynamic parameters and side effects during induction were recorded between both groups until the infusion of study drug. Results: The difference in mean HR at 15 and 30 minutes between both groups was found to be significant (p<0.05).Mean SBP in Etomidate group at 15 minutes was 120.87±10.28and in Propofol group was 111.27±11.26. Mean SBP in Etomidate group at 30 minutes was 120.03±10.87 and in Propofol group was 105.10±12.26. (p<0.05). Mean DBP at 10 minutes in Etomidate 76.07±9.5 and Propofol 70.6±11.24.Mean DBP at 15 minutes Etomidate 75.4±10.39 and Propofol 66.13±9.89.Mean DBP at 30 minutes Etomidate 76.17±10.41 and Propofol61.4±8.71. The difference in mean DBP at 10, 15 and 30 minutes between both groups was found to be significant (p<0.05).The difference in mean MAP at 10, 15 and 30 minutes between both groups was found to be significant (p<0.05).Etomidate and Propofol causes same effect on SPO2 in our study. Conclusion: Etomidate maintained hemodynamic stability. Heart rate changes were not significant between the two groups.
Authors and Affiliations
Ramesh Babu, Rajshekar Mudaraddi, Mohan . , Mahesh Sai
Keywords
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- EP ID EP520962
- DOI 10.26611/1015923
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