Hemostasis: A Cell Based Model
Journal Title: Journal of Physiology and Pharmacology Advances - Year 2015, Vol 5, Issue 5
Abstract
For centuries homeostasis have been explained on the basis of the coagulation cascade where two separate pathways converge on a common pathway leading to the formation of thrombin. Thrombin in turn converts fibrinogen to fibrin. Monitoring of homeostasis is done based on this cascade model but certain discrepancies exist between the laboratory finding and the clinical findings. Hence a new cell based model of coagulation was designed which could provide reliable explanations to the pitfalls noted in the cascade model. Tissue factor bearing cell and platelets are mainly involved in the coagulation process based on cell based model. This new concept of coagulation is already accepted in the clinical settings. Hence it is high time that this model be included in the standard physiology textbooks where still the cascade model is described in detail.
Authors and Affiliations
B. Bahuleyan
Keywords
Related Articles
- EP ID EP100556
- DOI -
- Views 116
- Downloads 0
Glucose Transporter 1 Gene Expression in Developmentally Regulated in Vitro derived Ovine Preimplantation Embryos
Precise control of gene expression during the preimplantation phase of development is important. The present study examined the expression pattern of GLUT 1 gene transcripts at various preimplantation developmental stage...
Resting Electrocardiogram of Top Athlete: Comparative Study between Football Players and Wrestlers in Senegal
Regular and intensive physical activity induces the "athlete's heart". So we compared the heart function of football players and wrestlers. We conducted a cross-sectional study from 01 April to 31 August 2014, involving...
Haematological and Biochemical Responses of Adult Rabbits to Aqueous Extract of Ocimum Gratissimum Leaves
An experiment which lasted for eight weeks was conducted to evaluate the haematological and biochemical responses of adult rabbits to aqueous extract of Ocimum gratissimum leaves. A total of thirty crossbred adult rabbit...
Massive Haemothorax and Tension Pneumothorax Due to Fractured Second Rib: Case Report
Massive haemothorax and tension pneumothorax due to injury of internal thoracic vein and second rib fracture after blunt trauma is very rare. Possible mechanisms of injury to the thoracic vein include fracture of an bony...
The Effect of Silymarin on the Ultra Structural of the Photoreceptor Layer in Streptozotocin-Induced Diabetic Rats
In present study silymarin was tested against damage of photoreceptor layer in streptozotocin-induced diabetic rats. Fifteen adult male wistar rats divided into three groups of five rats each. Diabetes was induced in two...