Hepatic Antioxidant Effect of Paroxetine in Rats Exposed to Chronic Restraint Model
Journal Title: Journal of Advances in Medicine and Medical Research - Year 2014, Vol 4, Issue 13
Abstract
Depressed mood, with its accompanying mental and physical stresses, could affect the progression and severity of several diseases e.g. hypertension, myocardial infarction, gastritis, peptic ulcer. The present animal study was done to investigate the potential antioxidant effect of paroxetine, as a selective serotonin reuptake inhibitor, to protect against chronic restraint stress-induced oxidative damage in the liver. Thirty albino rats were divided into 3 equal groups. Group 1 was control, non-stressed non-treated group. Group 2 was exposed to chronic restraint model by placing them in wire mesh cages exactly fit to their size for 6 hours daily for 21 days. Group 3 were also exposed to chronic restraint model for 21 days while they were administered by paroxetine 1 mg/kg/day ip during the restraint period. At the end of the study, liver transaminases were determined by commercial kits. The hepatic levels of glutathione peroxidase, catalase and thiobarbituric acid reactive substance were also determined by spectrophotometric methods. Glutathione repletion ability by hepatic cells with and without paroxetine treatment was also determined in all tested groups. The results showed a significant (p<0.05) increase in serum levels of transaminases and liver anti-oxidant enzymes while levels of thiobarbituric acid reactive substance were significantly (p<0.05) reduced in paroxetine-treated group compared with non-stressed non-treated control rats. Glutathione repletion ability was also significantly (p<0.05) increased in treated group to a level comparable to the control non-stressed non-treated values.
Authors and Affiliations
Sahar Mohamed Kamal
Keywords
Related Articles
- EP ID EP349233
- DOI 10.9734/BJMMR/2014/8559
- Views 72
- Downloads 0
Assessment of Birth Preparedness and Complication Readiness (BP/CR) among Pregnant Women in Orlu Local Government Area of Imo State, Nigeria
Birth Preparedness and Complication Readiness (BP/CR) are very important tenets of Focused Ante-Natal Care (FANC) aimed at reducing maternal morbidity and mortality. This study assessed birth preparedness and complicatio...
Nodular Fasciitis: An Uncommon Pediatric Parotid Region Mass
Aim: To describe a pediatric patient with an uncommon parotid region mass that was felt on ultrasound and clinical examination to be intraparotid. Case Presentation: A16-year-old female presented with a viral illness and...
Laparoscopic Sleeve Gastrectomy: A Single Egyptian Center Experience with Anesthetic and Surgical Complications
Introduction: Laparoscopic sleeve gastrectomy (LSG) as bariatric operation is gaining popularity nowadays. Many studies reported patient surgical outcome after LSG, however little is known about perioperative anesthesia-...
The WHO FRAX Calculator with and without BMD as an Indicator of Low BMD in Pakistani Women
Aims: BMD (bone mineral density) testing facilities are still scarce in Pakistan. We evaluated the predictive ability of FRAX with BMD (FRAX+) and FRAX without BMD (FRAX-) in a set of Pakistani females to assess their ro...
Biobanking: A Challenge Facing Pathologists in Egypt
Background: Biobanking today plays a key tool in biomedical research. Establishment and proper running of biobanks in developing countries is confronted with a number of challenges of legal, ethical, and financial nature...