Hepatitis Associated Aplastic Anemia (HAAA): A Rare Case of Severe Aplastic Anemia Following Acute Viral Hepatitis A
Journal Title: Pediatric Review: International Journal of Pediatric Research - Year 2016, Vol 3, Issue 4
Abstract
Hepatitis-associated aplastic anemia (HAAA) is acquired aplastic anemia in which marrow failure follows the development of hepatitis. HAAA was first described in 1955. It usually affects children and young adolescents. Immune mediated liver injury and bone marrow failure with involvement of activated lymphocytes may be proposed mechanism. We report a case of 17 year old female child who presented with fever, vomiting and yellow discoloration of urine with pallor and jaundice with pancytopenia. In our case report, Positive IgM Anti-HAV with aplastic bone marrow is found which is a rare association. Other viral markers are negative. Untreated HAAA has high mortality. HAAA has a very poor outcome. Management includes immunosuppression and anti-thymocyte globulin and ultimately bone marrow transplantation (BMT) may be required.
Authors and Affiliations
Dhaval Bhatt, Gaurav Garg, R. K. Gulati
Keywords
Related Articles
- EP ID EP224137
- DOI 10.17511
- Views 158
- Downloads 0
Relationship between ABO blood group system and falciparum malaria in paediatric age group
Background: The associations of ABO blood group with different diseases were being reported from time to time. Recent works from different parts of the world have shown that O blood group is less prone and AB and B group...
Patent ductus arteriosus – clinical profile and outcome after treatment in a tertiary care hospital
Background: Patent ductus arteriosus (PDA) is the commonest congenital heart disease seen in neonatal ICU. Methods: A prospective observational study was conducted in the neonatal intensive care unit of Vydehi institute...
Clinical profile and complications of acute malaria caused by different species of Plasmodium
Introduction: Malaria is more severe in children than in adults and 78% of all deaths due to malaria occur in children under 5years. Plasmodium vivax has long been considered to have benign course. However during past fe...
Self assessed symptoms and risk factors of anemia in urban school going adolescent girls
Introduction: Anemia prevalence is very high in adolescent girls. Anemia detection is not done adequately due to non specific symptoms. Risk factors for anemia have been identified and taken care of but still the prevale...
Study of hematological parameters among newborns with perinatal asphyxia
The aim of this original research article was to identify the blood parameters as predictors of perinatal asphyxia and its correlation with severity of asphyxia. Setting: Postnatal Wards and Sick newborn unit of Pediatri...