HEPATO PROTECTIVE EFFICACY OF TERMINALIA CHEBULA, TERMINALIA BELLIRICA, PHYLLANTHUS EMBLICA AND THEIR FORMULATION ON IMIDACLOPRID INDUCED LIVER TOXICITY BY HISTOPATHOLOGICAL AND BIOCHEMICAL PARAMETERS
Journal Title: International Journal of Pharmaceutical Sciences and Drug Research - Year 2015, Vol 7, Issue 5
Abstract
Terminalia chebula, Terminalia bellirica, Phyllanthus emblica and their formulations are used as a phytotherapeutic medicine for hepatic diseases. In the present study the effect of methanolic extract of herbal powder was administered against Imidacloprid in Albino Wistar Rats. Single dose of herbal (500 mg/kg/b.w) was given orally for 28 days to Imidacloprid toxicity exposed to rats. They were observed each hour and each day for 28 days for any changes in behavioural activity loss of ability to move, cramping, lethargy, muscle weakness, convulsion, irritation of the eye, excess salivation, change in gait. Clinical observations body weight, organ weight, biochemical analysis and histopathological examination were carried out. Administration of Imidacloprid, produced liver degeneration such as cytoplasmic vacuolation, mild vacuolar degeneration, mild hepatic damage in low dose (40 mg/kg b.w) and appearance of blood streaks, hepatic damage and severe vacuolar degenerations were observed in high dose of induction (80 mg/kg b.w). Animals were treated with the phytotherapeutic products of Terminalia chebula, Terminalia bellirica, Phyllanthus emblica and their formulations. Triphala extract was possessed more hepatoprotective activity, while comparing the four samples which was proved experimentally.
Authors and Affiliations
V. Eugin Amala, M. Jeyaraj
Keywords
Related Articles
- EP ID EP625087
- DOI -
- Views 55
- Downloads 0
BENZOTHIAZOLE: DIFFERENT METHODS OF SYNTHESIS AND DIVERSE BIOLOGICAL ACTIVITIES
Substituted 1, 3-benzothiazole derivatives are an important class of heterocyclic compounds. In recent years heterocyclic compounds analogues and derivatives have attracted strong interest due to their biological and pha...
A VALIDATED STABILITY INDICATING RP-HPLC METHOD DEVELOPMENT FOR ANTI CANCER DRUG ENZALUTAMIDE IN BULK AND PHARMACEUTICALS
A reproducible stability-indicating Reverse Phase-HPLC technique for the quantification of enzalutamide in in pharmaceuticals was developed and validated. Chromatography was achieved on Inertsil-ODS-C18 (250mm×4.6 mm) 5µ...
DEVELOPMENT AND OPTIMIZATION OF GASTRO-RETENTIVE FORMULATION OF HYDRALAZINE HCL
Hydralazine hydrochloride has a half-life of 2 to 4 hours with an oral bioavailability of 26-50%. Since hydralazine has a demethylating effect on various suppressor genes, it can be used in various types of cancer to sup...
EXTRACTIVE SPECTROPHOTOMETRIC METHODS FOR THE DETERMINATION OF GABAPENTIN IN PHARMACEUTICAL DOSAGE FORMS
Two simple, rapid, sensitive, accurate, precise and economic spectrophotometric methods have been developed for the estimation of Gabapentin (GBP) in pharmaceutical formulations. During the course of study, it was observ...
FORMULATION DEVELOPMENT AND OPTIMIZATION OF OLMESARTAN MEDOXOMIL IMMEDIATE RELEASE TABLETS
Olmesartan Medoxomil blocks the vasoconstrictor and aldosterone-secreting effects of angiotensin II by selectively binding to the AT1 angiotensin II receptor. ACE inhibitor is used in treatment of hypertension. The objec...