Hepatocellular carcinoma in hepatitis-negative patients with thalassemia intermedia: a closer look at the role of siderosis
Journal Title: Annals of Hepatology - Year 2013, Vol 12, Issue 1
Abstract
Patients with thalassemia are often exposed to several risk factors for developing hepatocellular carcinoma (HCC) due to their repeated transfusions. However, even transfusion-independent patients with thalassemia intermedia (TI) can develop HCC, which is mainly attributed to a state of iron overload. We report here two cases and review the literature for the association between TI and HCC. Along with our cases, a total of 36 cases of HCC in thalassemic patients were reported in the literature. Of these, 22 (61%) were TI patients with 6 (27%) of them being hepatitis B and C negative. There was no consistency in their characteristics; therefore, we recommended screening thresholds for HCC in TI patients based on their total liver iron concentration (LIC).
Authors and Affiliations
Joseph Maakaron, Maria Cappellini, Giovanna Graziadei, Jad Ayache, Ali Taher
Keywords
Related Articles
- EP ID EP78243
- DOI -
- Views 145
- Downloads 0
Clinical decisions in Hepatology - The pirfenidone case analysis
The safety and feasibility of large volume paracentesis performed by an experienced nurse practitioner
Due to time constraints, fewer physicians are performing large volume paracentesis (LVP) resulting in a longer wait time and more emergency department (ED) and hospital admissions. At our institution, after initial super...
LncRNA-Regulated Autophagy and its Potential Role in Drug-Induced Liver Injury
Background and aim. Autophagy and its regulated pathways participate in many important cellular physiology and pathological processes involving protein aggregates, damaged mitochondria, excessive peroxisomes, ribosomes,...
Prevalence of type 2 diabetes mellitus and chronic liver disease: A retrospective study of the association of two increasingly common diseases in Mexico
Background. Recent studies have demonstrated a relationship between insulin resistance (IR) and type 2 diabetes mellitus (T2DM). The aim of this study was to determine the prevalence of T2DM among patients with liver dis...
Acute phase proteins for the diagnosis of bacterial infection and prediction of mortality in acute complications of cirrhosis
Introduction. Bacterial infection is a frequent complication in patients with decompensated liver cirrhosis and is related to high mortality rates during follow-up of these individuals. We sought to evaluate the diagnost...