“HEPATOPROTECTIVE ACTIVITY OF ALCOHOLIC EXTRACT OF COLDENIA PROCUMBENS LINN. AGAINST PARACETAMOL INDUCED HEPATOTAOXICITY IN RATS
Journal Title: INTERNATIONAL JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH - Year 2015, Vol 3, Issue 1
Abstract
The alcoholic extract of Coldenia procumbens in normal saline (Vehicle) was evaluated for hepatoprotective activity in Wister albino rats by inducing hepatic injury with paracetamol (2g/kg body weight orally). Paracetamol induced hepatic damage was manifested by a significant increase in the activities of marker enzymes. Biochemical data exhibited significant hepatoprotective activity of alcoholic extract of Coldenia procumbens at oral dose of 200 and 400 mg/kg against paracetamol. Silymarin was used as reference standard also exhibited significant hepatoprotective activity against paracetamol. The biochemical observations were supplemented with histopathological examination of rat liver sections.
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